| 621173 | Anxa7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding; calcium-dependent protein binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN membrane fusion; response to calcium ion; response to phorbol 13-acetate 12-myristate; ASSOCIATED WITH breast cancer (orth olog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body; plasma membrane; chromaffin granule membrane (ortholog); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene | 15 | 3869180 | 3897827 | Rat | 184 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 731625 | ANXA7 | annexin A7 | Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two p rotein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008] | 10 | 73375101 | 73414058 | Human | 182 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 731626 | Anxa7 | annexin A7 | Enables GTPase-dependent fusogenic activity. Acts upstream of or within with a positive effect on ligand-gated ion channel signaling pathway; phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway; and positive regulation of insulin secretion. Acts upstream of or withi n several processes, including glial cell proliferation; intracellular calcium ion homeostasis; and intracellular water homeostasis. Located in several cellular components, including cytosol; nuclear envelope; and vesicle. Orthologous to human ANXA7 (annexin A7). [provided by Alliance of Genome Resources, Jul 2025] | 14 | 20505344 | 20530009 | Mouse | 208 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9053022 | Anxa7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN autophagy (ortholog); cell population proliferation (ortholog); epithelial cell differentiation (ortholog); ASS OCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); chromaffin granule membrane (ortholog); cytosol (ortholog) | NW_004955437 | 18394371 | 18421779 | Chinchilla | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11724371 | ANXA7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN cell population proliferation (ortholog); hemostasis (ortholog); intracellular calcium ion homeostasis (ortholog); ASSOCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); nuclear envelope (ortholog) | 10 | 69923353 | 69962980 | Bonobo | 51 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12249439 | ANXA7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN autophagy (ortholog); cell population proliferation (ortholog); epithelial cell differentiation (ortholog); ASS OCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); endoplasmic reticulum membrane (ortholog) | 4 | 23933959 | 23961968 | Dog | 54 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12699681 | Anxa7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN cell population proliferation (ortholog); hemostasis (ortholog); intracellular calcium ion homeostasis (ortholog); ASSOCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); nuclear envelope (ortholog) | NW_004936521 | 5639193 | 5671369 | Squirrel | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625931617 | Anxa7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN autophagy (ortholog); cell population proliferation (ortholog); epithelial cell differentiation (ortholog); ASS OCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); chromaffin granule membrane (ortholog); cytosol (ortholog) | | | | Black Rat | 42 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18928772 | Anxa7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN autophagy (ortholog); cell population proliferation (ortholog); epithelial cell differentiation (ortholog); ASS OCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); chromaffin granule membrane (ortholog); cytosol (ortholog) | | | | Naked Mole-Rat | 48 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18485352 | ANXA7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN cell population proliferation (ortholog); hemostasis (ortholog); intracellular calcium ion homeostasis (ortholog); ASSOCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); nuclear envelope (ortholog) | | | | Green Monkey | 49 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155249925 | anxa7 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14200648 | ANXA7 | annexin A7 | ENCODES a protein that exhibits calcium-dependent phospholipid binding (ortholog); GTPase-dependent fusogenic activity (ortholog); INVOLVED IN cell population proliferation (ortholog); hemostasis (ortholog); intracellular calcium ion homeostasis (ortholog); ASSOCIATED WITH breast cancer (ortholog); colon adenocarcinoma (ortholog); Liver Neoplasms (ortholog); FOUND IN alveolar lamellar body (ortholog); cytosol (ortholog); nuclear envelope (ortholog); INTERACTS WITH deoxynivalenol | | | | Pig | 52 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155257999 | anxa7.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155244468 | anxa7.S | | | | | | African Clawed Frog | | symbol | gene, null |
| 1584971 | Anxa7-ps1 | Annexin A7, pseudogene 1 | | 2 | 180980239 | 180982201 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 15038731 | Anxa7-ps1 | annexin A7, pseudogene 1 | | | | | Mouse | | symbol , PhenoGen | gene, pseudo |
| 7641052 | Anxa7-ps2 | Annexin A7, pseudogene 2 | | 7 | 25781829 | 25783008 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41063235 | Anxa7-ps3 | Annexin A7, pseudogene 3 | | X | 17178654 | 17183074 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
| 41070214 | Anxa7-ps4 | Annexin A7, pseudogene 4 | | 5 | 6835420 | 6838931 | Rat | | symbol , PhenoGen | gene, pseudo, MODEL [RefSeq] |
