ENCODES a protein that exhibits steroid dehydrogenase activity; INVOLVED IN androgen catabolic process; hippocampus development; response to resveratrol; FOUND IN cytosol; INTERACTS WITH 1,4-benzoquinone; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one
Enables androsterone dehydrogenase [NAD(P)+] activity. Predicted to be involved in glycoside metabolic process; prostaglandin metabolic process; and steroid metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in gut; liver; metanephros
; reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; alcohol dependence; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Jul 2025]