| 1310668 | Afap1l2 | actin filament associated protein 1-like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (ortholog); SH2 domain binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN inflammatory response (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulation of epidermal growth fa ctor receptor signaling pathway (ortholog); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran | 1 | 265969368 | 266065951 | Rat | 119 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1321706 | AFAP1L2 | actin filament associated protein 1 like 2 | Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. L ocated in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025] | 10 | 114280725 | 114405175 | Human | 108 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, VALIDATED [RefSeq] |
| 1321707 | Afap1l2 | actin filament associated protein 1-like 2 | Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulat ion of mitotic cell cycle. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including adipose tissue; genitourinary system; gut; hemolymphoid system gland; and nervous system. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2). [provided by Alliance of Genome Resources, Jul 2025] | 19 | 56900786 | 57017021 | Mouse | 136 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 9000249 | Afap1l2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (ortholog); SH2 domain binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN inflammatory response (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulation of epidermal growth fa ctor receptor signaling pathway (ortholog); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | NW_004955431 | 19275257 | 19378507 | Chinchilla | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11746925 | AFAP1L2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (inferred); SH2 domain binding (inferred); SH3 domain binding (inferred); INVOLVED IN inflammatory response (inferred); positive regulation of DNA-templated transcription (inferred); positive regulation of epidermal growth fa ctor receptor signaling pathway (inferred); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 10 | 110894774 | 111004373 | Bonobo | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12319458 | AFAP1L2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (inferred); SH2 domain binding (inferred); SH3 domain binding (inferred); INVOLVED IN inflammatory response (inferred); positive regulation of DNA-templated transcription (inferred); positive regulation of epidermal growth fa ctor receptor signaling pathway (inferred); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | 28 | 25137235 | 25228454 | Dog | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12451788 | Afap1l2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (inferred); SH2 domain binding (inferred); SH3 domain binding (inferred); INVOLVED IN inflammatory response (inferred); positive regulation of DNA-templated transcription (inferred); positive regulation of epidermal growth fa ctor receptor signaling pathway (inferred); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | NW_004936486 | 4606529 | 4697481 | Squirrel | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 284682497 | afap1l2 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18924869 | Afap1l2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (ortholog); INVOLVED IN inflammatory response (inferred); positive regulation of DNA-templated transcription (inferred); positive regulation of epidermal growth factor receptor signaling pathway (inferred); ASSOCIATED WITH sq uamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Naked Mole-Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18450902 | AFAP1L2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (inferred); SH2 domain binding (inferred); SH3 domain binding (inferred); INVOLVED IN inflammatory response (inferred); positive regulation of DNA-templated transcription (inferred); positive regulation of epidermal growth fa ctor receptor signaling pathway (inferred); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Green Monkey | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 14064541 | AFAP1L2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (inferred); SH2 domain binding (inferred); SH3 domain binding (inferred); INVOLVED IN inflammatory response (inferred); positive regulation of DNA-templated transcription (inferred); positive regulation of epidermal growth fa ctor receptor signaling pathway (inferred); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred) | | | | Pig | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626079920 | Afap1l2 | actin filament associated protein 1 like 2 | ENCODES a protein that exhibits protein tyrosine kinase activator activity (ortholog); SH2 domain binding (ortholog); SH3 domain binding (ortholog); INVOLVED IN inflammatory response (ortholog); positive regulation of DNA-templated transcription (ortholog); positive regulation of epidermal growth fa ctor receptor signaling pathway (ortholog); ASSOCIATED WITH squamous cell carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog) | | | | Black Rat | 13 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 286172067 | afap1l2.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 286814644 | afap1l2.S | | | | | | African Clawed Frog | | symbol | gene, null |