| 62064 | Adra1d | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity; identical protein binding (ortholog); INVOLVED IN positive regulation of vasoconstriction; negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortho log); neuron-glial cell signaling (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH polycystic ovary syndrome; diastolic heart failure (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH (R)-noradrenaline; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 17alpha-ethynylestradiol | 3 | 139246333 | 139262331 | Rat | 168 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 62356 | Adra1d | adrenergic receptor, alpha 1d | Enables alpha1-adrenergic receptor activity. Involved in neuron-glial cell signaling and regulation of blood pressure. Acts upstream of or within negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure and norepinephrine-e pinephrine vasoconstriction involved in regulation of systemic arterial blood pressure. Predicted to be active in plasma membrane. Is expressed in brain; diencephalon; and forebrain. Orthologous to human ADRA1D (adrenoceptor alpha 1D). [provided by Alliance of Genome Resources, Apr 2025] | 2 | 131387277 | 131404417 | Mouse | 185 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 734051 | ADRA1D | adrenoceptor alpha 1D | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-prote ins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008] | 20 | 4220630 | 4249287 | Human | 175 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 8926591 | Adra1d | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signal ing (ortholog); norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog) | NW_004955415 | 15000257 | 15022712 | Chinchilla | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11792717 | ADRA1D | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signaling (ortholog); norepinephrine-epineph rine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | 20 | 4242788 | 4271295 | Bonobo | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12438817 | Adra1d | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signaling (ortholog); norepinephrine-epineph rine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | NW_004936485 | 14514395 | 14538389 | Squirrel | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13395345 | ADRA1D | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signaling (ortholog); norepinephrine-epineph rine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH Naftopidil; phenylephrine | 24 | 17231771 | 17239110 | Dog | 40 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626049370 | Adra1d | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signal ing (ortholog); norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog) | | | | Black Rat | 20 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18909350 | Adra1d | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); identical protein binding (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signal ing (ortholog); norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Naked Mole-Rat | 37 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155243117 | adra1d | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 13920427 | ADRA1D | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signaling (ortholog); norepinephrine-epineph rine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred); INTERACTS WITH phenylephrine | | | | Pig | 40 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 18507822 | ADRA1D | adrenoceptor alpha 1D | ENCODES a protein that exhibits alpha1-adrenergic receptor activity (ortholog); INVOLVED IN negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure (ortholog); neuron-glial cell signaling (ortholog); norepinephrine-epineph rine vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ASSOCIATED WITH diastolic heart failure (ortholog); polycystic ovary syndrome (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred) | | | | Green Monkey | 38 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 155256233 | adra1d.L | | | | | | African Clawed Frog | | symbol | gene, null |
| 155243116 | adra1d.S | | | | | | African Clawed Frog | | symbol | gene, null |
