| 71014 | Adcy5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity; adenylate cyclase binding (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; heart development; PARTIC IPATES IN G protein mediated signaling pathway via Galphas family; glucagon signaling pathway; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH hypertension; type 2 diabetes mellitus; Animal Mammary Neoplasms (ortholog); FOUND IN endosome; sarcolemma; cilium (ortholog); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine | 11 | 78976861 | 79123343 | Rat | 230 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 736882 | ADCY5 | adenylate cyclase 5 | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is in hibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] | 3 | 123282296 | 123449090 | Human | 287 | symbol , COSMIC , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 736883 | Adcy5 | adenylate cyclase 5 | Enables adenylate cyclase activity; adenylate cyclase binding activity; and scaffold protein binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; locomotory behavior; and neuromuscular process controlling balance. Located in cilium and plasma membrane. Is expres sed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Parkinson's disease. Orthologous to human ADCY5 (adenylate cyclase 5). [provided by Alliance of Genome Resources, Jul 2025] | 16 | 34974933 | 35126108 | Mouse | 229 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 11761213 | ADCY5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN endosome (ortholog); sarcolemma (ortholog) | 3 | 120380094 | 120545725 | Bonobo | 80 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12099025 | ADCY5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity; calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN cAMP biosynthetic process; adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled rec eptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN cilium (ortholog); endosome (ortholog); membrane (ortholog) | 33 | 26345617 | 26490120 | Dog | 94 | symbol | gene, protein-coding, PROVISIONAL [RefSeq] |
| 12536135 | Adcy5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN endosome (ortholog); sarcolemma (ortholog) | NW_004936725 | 1751272 | 1897937 | Squirrel | 81 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626005698 | Adcy5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); adenylate cyclase binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN cilium (ortholog); endosome (ortholog); membrane (ortholog) | | | | Black Rat | 70 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 20866367 | ADCY5 | adenylate cyclase 5 | | | | | Green Monkey | | symbol | gene, protein-coding |
| 626185524 | adcy5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 18902742 | Adcy5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); adenylate cyclase binding (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN endosome (ortholog); membrane (ortholog); sarcolemma (ortholog) | | | | Naked Mole-Rat | 76 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18360295 | ADCY5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN endosome (ortholog); sarcolemma (ortholog) | | | | Green Monkey | 78 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 626181233 | adcy5 | | | | | | Tropical Clawed Frog | | symbol | gene, null |
| 14217095 | ADCY5 | adenylate cyclase 5 | ENCODES a protein that exhibits adenylate cyclase activity (ortholog); calcium- and calmodulin-responsive adenylate cyclase activity (ortholog); INVOLVED IN adenylate cyclase-activating dopamine receptor signaling pathway (ortholog); adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adenylate cyclase-inhibiting dopamine receptor signaling pathway (ortholog); PARTICIPATES IN dopamine signaling pathway via D1 family of receptors; dopamine signaling pathway via D2 family of receptors; endothelin signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); Birth Weight (ortholog); carcinoma (ortholog); FOUND IN endosome (ortholog); sarcolemma (ortholog); INTERACTS WITH deoxynivalenol; zearalenone | | | | Pig | 84 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 8918324 | LOC102014808 | adenylate cyclase type 5 | | NW_004955427 | 22460766 | 22596167 | Chinchilla | | ensembl_gene_symbol , old_gene_symbol | gene, protein-coding, MODEL [RefSeq] |
| 16566497 | AC112503.1 | novel transcript, antisense to ADCY5 | | | | | Human | | name | gene, lncrna |