| 1304697 | Actl7a | actin-like 7a | INVOLVED IN acrosome assembly (ortholog); fertilization (ortholog); spermatid development (ortholog); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN protein-containing complex; acrosomal vesicle (ortholog); cytoplas m (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A | 5 | 76242201 | 76245647 | Rat | 61 | symbol , PhenoGen | gene, protein-coding, VALIDATED [RefSeq] |
| 1312292 | ACTL7A | actin like 7A | The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellula r processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008] | 9 | 108862266 | 108863756 | Human | 75 | symbol , COSMIC , description , Human Proteome Map | gene, protein-coding, REVIEWED [RefSeq] |
| 1312293 | Actl7a | actin-like 7a | Involved in acrosome assembly and fertilization. Located in acrosomal vesicle; male germ cell nucleus; and motile cilium. Colocalizes with Golgi apparatus. Human ortholog(s) of this gene implicated in male infertility and spermatogenic failure 86. Orthologous to human ACTL7A ACTL7A (actin like 7A). [provided by Alliance of Genome Resources, Jul 2025] | 4 | 56743422 | 56744925 | Mouse | 61 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 8763191 | Actl7a | actin like 7A | INVOLVED IN acrosome assembly (ortholog); fertilization (ortholog); spermatid development (ortholog); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); Golgi apparatu s (ortholog) | NW_004955419 | 18102980 | 18106405 | Chinchilla | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 11923383 | ACTL7A | actin like 7A | INVOLVED IN acrosome assembly (inferred); cell differentiation (inferred); fertilization (inferred); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred); cytoskeleton (i nferred) | 9 | 80014898 | 80016379 | Bonobo | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12279693 | ACTL7A | actin like 7A | INVOLVED IN acrosome assembly (inferred); cell differentiation (inferred); fertilization (inferred); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred); cytoskeleton (i nferred); INTERACTS WITH masitinib | 11 | 64031305 | 64033908 | Dog | 30 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 12653217 | Actl7a | actin like 7A | INVOLVED IN acrosome assembly (inferred); cell differentiation (inferred); fertilization (inferred); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred); cytoskeleton (i nferred) | NW_004936559 | 3983288 | 3986932 | Squirrel | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 13972743 | ACTL7A | actin like 7A | INVOLVED IN acrosome assembly (ortholog); fertilization (ortholog); spermatid development (ortholog); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN cytoplasm (ortholog); male germ cell nucleus (ortholog); motile ci lium (ortholog) | | | | Pig | 27 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18918153 | Actl7a | actin like 7A | INVOLVED IN acrosome assembly (inferred); cell differentiation (inferred); fertilization (inferred); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred); cytoskeleton (i nferred) | | | | Naked Mole-Rat | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 625833158 | Actl7a | actin like 7A | INVOLVED IN acrosome assembly (ortholog); fertilization (ortholog); spermatid development (ortholog); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); Golgi apparatu s (ortholog) | | | | Black Rat | 23 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 18683185 | ACTL7A | actin like 7A | INVOLVED IN acrosome assembly (inferred); cell differentiation (inferred); fertilization (inferred); ASSOCIATED WITH bladder urothelial carcinoma (ortholog); male infertility (ortholog); spermatogenic failure 86 (ortholog); FOUND IN acrosomal vesicle (inferred); cytoplasm (inferred); cytoskeleton (i nferred) | | | | Green Monkey | 26 | symbol | gene, protein-coding, MODEL [RefSeq] |
| 1313810 | ACTL7B | actin like 7B | The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellula r processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known. [provided by RefSeq, Jul 2008] | 9 | 108854588 | 108855986 | Human | 36 | description | gene, protein-coding, REVIEWED [RefSeq] |
