Abcc5 Gene Search Result

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14 records found for search term Abcc5

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RGD ID	Symbol	Name	Description	Chr	Start	Stop	Species	Annotations	Match	Type
70913	Abcc5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); ATPase-coupled transmembrane transporter activity (ortholog); INVOLVED IN response to insulin; response to lipopolysaccharide; cAMP transport (ortholog); PARTICIPATES IN mul ... (more) tidrug resistance-associated protein mediated transport pathway; azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; ASSOCIATED WITH Reperfusion Injury; Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN basolateral plasma membrane; perinuclear region of cytoplasm; apical plasma membrane (ortholog); INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; 17beta-estradiol	11	93975579	94071659	Rat	314	symbol , PhenoGen , old_gene_symbol	gene, protein-coding, VALIDATED [RefSeq]
734363	ABCC5	ATP binding cassette subfamily C member 5	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This p ... (more) rotein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]	3	183919934	184017884	Human	296	symbol , COSMIC , Human Proteome Map	gene, protein-coding, REVIEWED [RefSeq]
737464	Abcc5	ATP-binding cassette, sub-family C member 5	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, G ... (more) CN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The human protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that the human protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]	16	20150053	20245178	Mouse	318	symbol , PhenoGen , old_gene_symbol	gene, protein-coding, REVIEWED [RefSeq]
8903208	Abcc5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); efflux transmembrane transporter activity (ortholog); INVOLVED IN cAMP transport (ortholog); cGMP transport (ortholog); export across plasma membrane (ortholog); PARTICIPATE ... (more) S IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); membrane (ortholog)	NW_004955420	23447920	23522732	Chinchilla	43	symbol	gene, protein-coding, MODEL [RefSeq]
12010296	ABCC5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); ATP binding (inferred); INVOLVED IN hyaluronan biosynthetic process (ortholog); response to insulin (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN az ... (more) athioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)	3	180956139	181054112	Bonobo	54	symbol	gene, protein-coding, MODEL [RefSeq]
12121151	ABCC5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); ATP binding (inferred); INVOLVED IN hyaluronan biosynthetic process (ortholog); response to insulin (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN az ... (more) athioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); INTERACTS WITH bisphenol A	34	16856624	16947844	Dog	56	symbol	gene, protein-coding, PROVISIONAL [RefSeq]
12586771	Abcc5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); ATP binding (inferred); INVOLVED IN hyaluronan biosynthetic process (ortholog); response to insulin (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN az ... (more) athioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)	NW_004936578	5838044	5916287	Squirrel	53	symbol	gene, protein-coding, MODEL [RefSeq]
18505009	ABCC5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); ATP binding (inferred); INVOLVED IN hyaluronan biosynthetic process (ortholog); response to insulin (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN az ... (more) athioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)				Green Monkey	53	symbol	gene, protein-coding, MODEL [RefSeq]
18911614	Abcc5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); ATP binding (inferred); INVOLVED IN hyaluronan biosynthetic process (ortholog); response to insulin (ortholog); response to lipopolysaccharide (ortholog); PARTICIPATES IN az ... (more) athioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog)				Naked Mole-Rat	54	symbol	gene, protein-coding, MODEL [RefSeq]
284384318	abcc5						Tropical Clawed Frog		symbol	gene, null
14161851	ABCC5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type glutathione S-conjugate transporter activity (inferred); ABC-type transporter activity (inferred); ABC-type xenobiotic transporter activity (inferred); INVOLVED IN hyaluronan biosynthetic process (ortholog); response to insulin (ortholog); response to lipopol ... (more) ysaccharide (ortholog); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN perinuclear region of cytoplasm (ortholog); INTERACTS WITH deoxynivalenol				Pig	56	symbol	gene, protein-coding, MODEL [RefSeq]
625996063	Abcc5	ATP binding cassette subfamily C member 5	ENCODES a protein that exhibits ABC-type transporter activity (ortholog); ABC-type xenobiotic transporter activity (ortholog); efflux transmembrane transporter activity (ortholog); INVOLVED IN cAMP transport (ortholog); cGMP transport (ortholog); export across plasma membrane (ortholog); PARTICIPATE ... (more) S IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); pancreatic cancer (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); membrane (ortholog)				Black Rat	43	symbol	gene, protein-coding, MODEL [RefSeq]
288083254	abcc5.L						African Clawed Frog		symbol	gene, null
6481332	ABCC5-AS1	ABCC5 antisense RNA 1	INTERACTS WITH lipopolysaccharide; S-(1,2-dichlorovinyl)-L-cysteine	3	184006338	184011419	Human	2	symbol , COSMIC , name , Human Proteome Map	gene, ncrna, VALIDATED [RefSeq]