Strain Report - Rat Genome Database

Name: SD- Pax6 Sey2 /Mce
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Pax6^Sey2/Mce

Symbol:

SD-Pax6^Sey2/Mce

Strain:

SD-Pax6^Sey2

Substrain:

Mce

RGD ID:

9685623

Citation ID:

RRID:RGD_9685623

Ontology ID:

RS:0003848

Alleles:

Pax6^Sey2

Also Known As:

NBRP Rat No: 0722; rSey²; rSey2; SD-Pax6Sey2/Mce; SD-Pax6^[Sey2]/Mce

Type:

mutant

Available Source:

National BioResource Project for the Rat in Japan

Origination:

Department of Ophthalmology, Okayama University Medical School, Okayama, Japan

Description:

This rat (developed spontaneous microphthalmia) was found in a SD rat colony at Yamanouchi Pharma Inc. (Astellas Pharma Inc.)Genomic DNA analysis from mutants revealed a single base(c) insertion, resulting in a abnormal stop codon at 33-bp downstream from the insertion site due to frameshift.

Coat Color:

Albino

Inbred Generations:

F15

Last Known Status:

Cryopreserved Sperm (as of 2017-02-23)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	92,128,772 - 92,157,022	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	3	95,700,241 - 95,728,682	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	3	102,320,059 - 102,348,223	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	3	91,127,605 - 91,149,178	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal abducens nerve morphology (IAGP)

abnormal behavioral response to light (IAGP)

abnormal hypoglossal nerve morphology (IAGP)

abnormal social/conspecific interaction behavior (IAGP)

decreased fear-related response (IAGP)

decreased serotonin level (IAGP)

decreased vertical activity (IAGP)

decreased vocalization (IAGP)

supernumerary incisors (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Study of Pax6 mutant rat revealed the association between upper incisor formation and midface formation.	Kriangkrai R, etal., Dev Dyn. 2006 Aug;235(8):2134-43.
2.	Pax-6 is involved in the specification of hindbrain motor neuron subtype.	Osumi N, etal., Development 1997 Aug;124(15):2961-72.
3.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
5.	Evaluation of Pax6 mutant rat as a model for autism.	Umeda T, etal., PLoS One. 2010 Dec 21;5(12):e15500. doi: 10.1371/journal.pone.0015500.

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	one base (C)insertion in the downstream encoding region of the Pax6 gene is observed	731242
strain_characteristics	exhibit abnormal motor neuron development of the hindbrain	731242
strain_characteristics	homozygous rats: embryonic lethality heterozygous rats: microphthalmia	1302502
strain_reproduction	Mating between heterozygous rats. heterozygous rats is identified by microphthalmia.	1302502

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2017-02-23	SD-Pax6^Sey2/Mce	SD-Pax6^Sey2Mce	Symbol updated	68687	APPROVED
2017-02-23	SD-Pax6^Sey2/Mce	SD-Pax6^Sey2Mce	Symbol updated	68687	APPROVED
2015-05-28	SD-Pax6^Sey2Mce	SD-Pax6^Sey2Mce	Name updated	68913	APPROVED
2015-05-28	SD-Pax6^Sey2Mce	SD-Pax6^Sey2Mce	Name updated	68913	APPROVED

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Pax6Sey2/Mce

Mammalian Phenotype

Strain: SD-Pax6^Sey2/Mce