Strain Report - Rat Genome Database
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Strain: MR/N

Symbol: MR/N
Strain: MR
Substrain: N
Full Name: Maudsely reactive
RGD ID: 70449
RRID: RGD_70449
Ontology ID: RS:0000589
Also known as: MR; RRRC:00173
Type: inbred
Source: NIH Autoimmune Rat Model Repository and Development Center
Origin: Origin: as for MNR except selection was for high defecation response in the open field. To Harrington in 1965 at F25 and to NIH in 1964 at F18+ (Hansen et al 1982).
Genetic Markers: a, c, h
Coat Color: Albino
Inbred Generations: F86 (Pit)
Last Known Status: Unknown






Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References


Region

Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
MR/N (KNAW) 543
MR/N (KNAW) 608
MR/N (MCW) 1460


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_behavior Show increased motor activation as compared to MNR/N to a low dose of alcohol. Females exhibit greater motor activation. 1358541
strain_characteristics Compared with MNR, the strain has a high open-field defecation, low ambulation, low rearing, low shock avoidance conditionability and tends to be more emotional in a wide range of behaviour (Broadhurst 1975), and have a higher preference for ethanol (Brewster 1968). Also differs from MNR in norepinephrine concentration in hypothalamus, heart, spleen and adrenal glands, suggesting that the sympathetic system might be functionally related to behavioural differences between the strains (Liang and Blizzard 1978). Lower specific benzodiazepine binding than MNR in hippocampus, hypothalamus, midbrain, medulla/pons and spinal cord, which might be a biological basis for differences in emotional behaviour (Robertson et al 1978). Long emergence latency in a novel environment in females (12/12) and also into a familiar environment in males (11/12) (Harrington 1971a). High open field defecation (1/12 males 2/12 females) (Harrington 1972). Shows substantial habituation to acoustic startle stimulous (Commissaris et al 1988). mRNA and protein populations in the brains of MR and MNR have been studied by Whatley et al (1992). Good breeding performance (4/12) and large litter size (2/12) (Hansen et al 1973). See also MNR. 1004
strain_characteristics Compared with MNR, the strain has a high open-field defecation, low ambulation, low rearing, low shock avoidance conditionability and tends to be more emotional in a wide range of behaviour (Broadhurst 1975), and have a higher preference for ethanol (Brewster 1968). Also differs from MNR in norepinephrine concentration in hypothalamus, heart, spleen and adrenal glands, suggesting that the sympathetic system might be functionally related to behavioural differences between the strains (Liang and Blizzard 1978). Lower specific benzodiazepine binding than MNR in hippocampus, hypothalamus, midbrain, medulla/pons and spinal cord, which might be a biological basis for differences in emotional behaviour (Robertson et al 1978). Long emergence latency in a novel environment in females (12/12) and also into a familiar environment in males (11/12) (Harrington 1971a). High open field defecation (1/12 males 2/12 females) (Harrington 1972). Shows substantial habituation to acoustic startle stimulous (Commissaris et al 1988). mRNA and protein populations in the brains of MR and MNR have been studied by Whatley et al (1992). Good breeding performance (4/12) and large litter size (2/12) (Hansen et al 1973). See also MNR. 634612

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-11-12 MR/N  Maudsely reactive  MR    Symbol Updated 728213 APPROVED