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Strain: BUF/Mna

Symbol: BUF/Mna
Strain: BUF
Substrain: Mna
RGD ID: 61118
RRID: RGD_61118
Ontology ID: RS:0000165
Alleles: Bsis
Also known as: NBRP Rat No: 0200; MDC-02-71; Buffalo Rat
Type: inbred
Source: National BioResource Project for the Rat in Japan
Origin: Strain originated from Heston 1946 from Buffalo stock of H. Morris. To NIH in 1950 at F10.
Coat Color: albino
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Cancer; Urology






Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
thymus weight to body weight ratio
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
total plasma bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References


Region

Strain QTL Data
Symbol Name Trait
Pur1 Proteinuria QTL 1 total urine protein amount   (VT:0000032)    
Pur16 Proteinuria QTL 16 total urine protein amount   (VT:0000032)    
Thym1 Thymus enlargement QTL 1 thymus mass   (VT:0004954)    
Thym2 Thymus enlargement QTL 2 thymus mass   (VT:0004954)    
Thym3 Thymus enlargement QTL 3 thymus mass   (VT:0004954)    
Thym4 Thymus enlargement QTL 4 thymus mass   (VT:0004954)    
Tsu1 Thymus enlargement suppressive QTL 1 thymus mass   (VT:0004954)    
Damaging Variants
Number of Damaging Variants
SampleRnor_6.0Rnor_5.0RGSC_v3.4
BUF/MNa (KyushuU) 1320


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Actr3 is mutated in this strain causing L111F substitution 2292230
strain_characteristics (WKY/NCrj x BUF/Mna)F1 x BUF/Mna backcross rats were studied for thymus enlargement. 634747
strain_life_disease They develop muscle atrophy and nephrosis. 1302468
strain_life_disease These develop thymoma at the age of 9 months which reaches its maximum at 12 months. 634729
strain_reproduction sib mating 1302468

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 BUF/Mna    BUF/Mna    Name updated 68913 APPROVED
2012-05-10 BUF/Mna    BUF/Mna    Name updated 68913 APPROVED