Strain Report - Rat Genome Database

Name: FHH-Chr 1 BN - Sorcs1 em1Mcwi-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: FHH-Chr 1^BN-Sorcs1^em1Mcwi-/-

Symbol:

FHH-Chr 1^BN-Sorcs1^em1Mcwi-/-

Strain:

FHH-Chr 1^BN-Sorcs1^em1-/Sorcs1^em1-

Substrain:

Mcwi

Full Name:

FHH-Chr 1^BN-Sorcs1^em1Mcwi-/Sorcs1^em1Mcwi-

RGD ID:

5688107

Citation ID:

RRID:RGD_5688107

Ontology ID:

RS:0003156

Alleles:

Sorcs1^em1Mcwi

Previously known as:

FHH-Chr 1BN-Sorcs1em1Mcwi-/-; FHH-Chr 1BN-Sorcs1em1Mcwi/1Mcwi; FHH-Chr 1^BN-Sorcs1^em1Mcwi/1Mcwi; FHH-Chr 1BN-Sorcs1em1Mcwi-/Sorcs1em1Mcwi-

Type:

mutant

Source:

PhysGen Knockouts

Origin:

ZFN mutant founders were backcrossed with FHH-Chr 1^BN/Mcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation is a 14-bp frameshift deletion mutation in exon 7.

Genetic Status:

Homozygous

Last Known Status:

Cryopreserved Sperm (as of 2021-11-03)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	249,080,662 - 249,594,520	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	269,965,824 - 270,473,097	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	277,404,996 - 277,912,261	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	255,767,411 - 256,279,565	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteinuria (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

mean arterial blood pressure

body weight

heart wet weight

right kidney wet weight

left kidney wet weight

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine creatinine excretion rate

References

References - curated


1.	Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2.	Lazar J, etal., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18.
3.	PhysGen Knockout strains
4.	RGD Automated Pipelines

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-03-31	FHH-Chr 1^BN-Sorcs1^em1Mcwi-/-	FHH-Chr 1^BN-Sorcs1^em1Mcwi-/Sorcs1^em1Mcwi-	FHH-Chr 1^BN-Sorcs1^em1Mcwi-/-	FHH-Chr 1^BN-Sorcs1^em1Mcwi-/Sorcs1^em1Mcwi-	Name/symbol updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: FHH-Chr 1BN-Sorcs1em1Mcwi-/-

Related Phenotype Data for Term "FHH-Chr 1BN-Sorcs1em1Mcwi-/-" (RS:0003156)

Strain: FHH-Chr 1^BN-Sorcs1^em1Mcwi-/-