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Strain: FHH-Chr 1BN-Sorcs1em1Mcwi-/-

Symbol: FHH-Chr 1BN-Sorcs1em1Mcwi-/-
Strain: FHH-Chr 1BN-Sorcs1em1-/Sorcs1em1-
Substrain: Mcwi
Full Name: FHH-Chr 1BN-Sorcs1em1Mcwi-/Sorcs1em1Mcwi-
RGD ID: 5688107
Citation ID: RRID:RGD_5688107
Ontology ID: RS:0003156
Alleles: Sorcs1em1Mcwi
Also Known As: FHH-Chr 1BN-Sorcs1em1Mcwi-/-; FHH-Chr 1BN-Sorcs1em1Mcwi/1Mcwi; FHH-Chr 1BN-Sorcs1em1Mcwi/1Mcwi; FHH-Chr 1BN-Sorcs1em1Mcwi-/Sorcs1em1Mcwi-; FHH-Chr 1^[BN]-Sorcs1^[em1Mcwi-/-]
Type: mutant
Available Source: Not Available
Origination: PhysGen Knockouts
Description: ZFN mutant founders were backcrossed with FHH-Chr 1BN/Mcwi to get heterozygous offsprings which were intercrossed and offsprings maintained as homozygous and heterozygous breeders. The resulting mutation is a 14-bp frameshift deletion mutation in exon 7.
Genetic Status: Homozygous
Last Known Status: Cryopreserved Sperm (as of 2021-11-03)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21249,207,764 - 249,207,777RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01269,965,824 - 270,473,097RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01277,404,996 - 277,912,261RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41255,767,411 - 256,279,565RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Knockout rats via embryo microinjection of zinc-finger nucleases. Geurts AM, etal., Science. 2009 Jul 24;325(5939):433.
2. SORCS1 contributes to the development of renal disease in rats and humans. Lazar J, etal., Physiol Genomics. 2013 Aug 15;45(16):720-8. doi: 10.1152/physiolgenomics.00089.2013. Epub 2013 Jun 18.
3. PhysGen Knockouts PhysGen Knockout strains
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Sorcs1em1Mcwi-var1 chr1 249207764 249207777 CCGGGTCAATGTAT - deletion mRatBN7.2

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-31 FHH-Chr 1BN-Sorcs1em1Mcwi-/-  FHH-Chr 1BN-Sorcs1em1Mcwi-/Sorcs1em1Mcwi-  FHH-Chr 1BN-Sorcs1em1Mcwi-/-  FHH-Chr 1BN-Sorcs1em1Mcwi-/Sorcs1em1Mcwi-  Name/symbol updated 68913 APPROVED