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Strain: F344-Tg(HIV)1Hsd

Symbol: F344-Tg(HIV)1Hsd
Strain: F344-Tg(HIV)1
Substrain: Hsd
RGD ID: 42722004
Citation ID: RRID:RGD_42722004
Ontology ID: RS:0004864
Type: transgenic
Available Source: Not Available
Description: Noninfectious clone containing gag-pol-deleted HIV-1 provirus under the viral LTR promoter was microinjected into fertilized one-cell Sprague�Dawley � Fisher 344/NHsd F1. Female founder with opaque cataracts was mating with wil-type Fischer 344/NHsd. Tg rats from line 1 contained 20�25 copies.
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. HIV-1 transgene expression in rats causes oxidant stress and alveolar epithelial barrier dysfunction. Lassiter C, etal., AIDS Res Ther. 2009 Feb 4;6:1. doi: 10.1186/1742-6405-6-1.
2. An HIV-1 transgenic rat that develops HIV-related pathology and immunologic dysfunction. Reid W, etal., Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9271-6. doi: 10.1073/pnas.161290298.
3. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
4. Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats. Vikulina T, etal., Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13848-53. doi: 10.1073/pnas.1003020107. Epub 2010 Jul 19.


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