Strain Report - Rat Genome Database

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Strain: WAG-F8m1Ycb

Symbol: WAG-F8m1Ycb
Strain: WAG-F8m1
Substrain: Ycb
RGD ID: 2314904
Citation ID: RRID:RGD_2314904
Ontology ID: RS:0003433
Alleles: F8m1Ycb
Previously known as: WAG-F8m1Ycb; WAG-F8m1Ycb
Type: mutant
Source: Comparative Medicine, Yale University, Connecticut
Origin: This mutant strain carrying a naturally occurring missense mutation displays inherited coagulopathy was arising in an inbred colony of WAG/RijYcb (RGD:2314861). Mutation in the nucleotide 578 of the rat F8 gene changes amino acid 193 in the rat protein(amino acid 176 in human)from Leucine to Proline.
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.218140,848 - 172,330RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.018367,862 - 399,242RGD_MAPPER_PIPELINERnor6.0
Rnor_5.018413,447 - 444,491RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.418121,134 - 162,008RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. WAG-F8(m1Ycb) rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Booth CJ, etal., J Thromb Haemost. 2010 Nov;8(11):2472-7. doi: 10.1111/j.1538-7836.2010.03978.x.
2. Strains registered by Dr. Carmen J Booth Personal communication between Dr. Carmen J Booth and the RGD curators.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
F8m1Ycb-var1 chr18 145719 145719 T C point_mutation mRatBN7.2
F8m1Ycb-var1 chr18 394478 394478 T C point_mutation Rnor_6.0

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-05-29 WAG-F8m1Ycb    WAG-F8m1Ycb    Symbol and/or name change 68913 APPROVED
2013-06-17 WAG-F8m1Ycb    WAG-F8m1Ycb    Name updated 68913 APPROVED
2013-06-17 WAG-F8m1Ycb    WAG-F8m1Ycb    Name updated 68913 APPROVED