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Strain Registration

Strain: GK/Far

Symbol: GK/Far
Strain: GK
Substrain: Far
Full Name: Goto-Kakizaki
RGD ID: 1579710
Citation ID: RRID:RGD_1579710
Ontology ID: RS:0001316
Also Known As: GK/Rfar; GKFL
Type: inbred
Available Source: Not Available
Origination: James A. Haley Veterans Hospital, Tampa Florida
Description: Generated by selective brother x sister breeding of 18 non-diabetic Jcl:Wistar rats which were glucose intolerant on oral glucose tolerant tests. This colony is from F36 generation of the Japanese colony provided by Drs. Suzuki and Toyota of Tokoku University , Sendai Japan.
Last Known Status: Unknown






  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GK/FarRatAlbuminuria  IAGP 1303373 RGD 
GK/FarRattype 2 diabetes mellitus  IAGP 1303373 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GK/FarRatimpaired glucose tolerance  IAGP 1303373 RGD 
GK/FarRatincreased circulating cholesterol level  IAGP 1303373compared to BN/NHsdMcwiRGD 
GK/FarRatincreased circulating triglyceride level  IAGP 1303373compared to BN/NHsdMcwiRGD 
GK/FarRatincreased kidney weight  IAGP 1303373compared to BN/NHsdMcwiRGD 
GK/FarRatincreased renal glomerulus basement membrane thickness  IAGP 1303373compared to BN/NHsdMcwiRGD 
GK/FarRatrenal glomerulus hypertrophy  IAGP 1303373compared to BN/NHsdMcwiRGD 

#
Reference Title
Reference Citation
1. Atrial natriuretic hormone prohormone gene expression in cardiac and extra-cardiac tissues of diabetic Goto-Kakizaki rats. Gower WR Jr, etal., Mol Cell Biochem. 2003 Oct;252(1-2):263-71.
2. Initial characterization of a rat model of diabetic nephropathy. Nobrega MA, etal., Diabetes 2004 Mar;53(3):735-42.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. Schlick NE, etal., Am J Physiol Cell Physiol. 2006 Dec;291(6):C1183-92. Epub 2006 Jul 19.




Note Type Note Reference
strain_phys_biochem Have a defect in synthesizing or releasing functional chiro-inositol-containing inositol phosphoglycan (IPG) and also IPG-regulated intracellular gllucose metabolism is defective. 1578805
strain_phys_biochem Atrial natriuretic hormone (ANH) prohormone mNA expression was increased in the ventricle, lung, kidney and stomach 1578805