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Strain Registration

Strain: SD-Tspoem1Vpl

Symbol: SD-Tspoem1Vpl
Strain: SD-Tspoem1
Substrain: Vpl
RGD ID: 150429828
Citation ID: RRID:RGD_150429828
Ontology ID: RS:0005062
Alleles: Tspoem1Vpl
Also Known As: SD-Tspoem1Vpap; SD-Tspo^[em1Vpl]
Type: mutant
Available Source: Not Available
Origination: McGill University and Genome Quebec Innovation Centre (Montreal, Canada)
Description: Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat5 founders using the following primer pairs: CKOZFN-F: 50-AGAGCATACTCTTGCCGTCG-30 and CKOZFN-R:50-ACTCCTAAAGGGGTTGCAGG-30; Normal PCRs generated 362 bp for the WT and 273 bp for the mutant,(89 bp deletion).
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27114,720,188 - 114,730,450RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.07124,460,358 - 124,470,610RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07124,449,361 - 124,459,090RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.47121,597,084 - 121,599,342RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis. Owen DR, etal., Biochem J. 2017 Nov 21;474(23):3985-3999. doi: 10.1042/BCJ20170648.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-10-01 SD-Tspoem1Vpl    SD-Tspoem1Vpap    Symbol and/or name change 68913 APPROVED