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Strain: RCS/LavRrrc

Symbol: RCS/LavRrrc
Strain: RCS
Substrain: LavRrrc
Full Name: royal college of surgeons rat
RGD ID: 1358258
RRID: RGD_1358258
Ontology ID: RS:0000660
Also known as: RRRC:00314
Type: inbred
Source: Retinal Degeneration Rat Model Resource , Rat Resource and Research Center
Origin: Developed before 1965 by Sidman from stock obtained from Sorsby of the Royal College of Surgeons, London.
Genetic Markers: Hooded
Inbred Generations: F101
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-30)





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Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These are tan-hooded, pink-eyed animals. 632096
strain_life_disease They have inherited retinal dystrophy as a result of genetic defect in retinal pigment epithelium. 632096
strain_life_disease Mutation in the Mertk is responsible for retinal degeneration where shed outer segments are phagocytosed by the retinal pigment epithelial (RPE) and metabolites recycled to the photoreceptors.  
strain_other When reared in the dark these have a greater accumulation of rhodopsin in the eyes. 632096

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-23 RCS/LavRrrc  royal college of surgeons rat  RCS/Lav  royal college of surgeons rat  Name/Symbol updated 68913 APPROVED