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Strain: RCS/LavRrrc

Symbol: RCS/LavRrrc
Strain: RCS
Substrain: LavRrrc
Full Name: royal college of surgeons rat
RGD ID: 1358258
Citation ID: RRID:RRRC_00314
Ontology ID: RS:0000660
Type: inbred
Available Source: Retinal Degeneration Rat Model Resource , Rat Resource and Research Center
Origination: Retinal Degeneration Rat Model Resource , Rat Resource and Research Center
Description: Originally developed before 1965 by Sidman from stock obtained from Sorsby of the Royal College of Surgeons, London. Then to University of California- San Francisco, School of Medicine, deposited to Rat Resource & Research Center.
Genetic Markers: Hooded
Inbred Generations: F101
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm (as of 2018-11-30)

Disease Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References - curated
# Reference Title Reference Citation
1. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. D'Cruz PM, etal., Hum Mol Genet 2000 Mar 1;9(4):645-51.
2. Influence of eye pigmentation and light deprivation on inherited retinal dystrophy in the rat. LaVail MM and Battelle BA, Exp Eye Res 1975 Aug;21(2):167-92.
3. Photoreceptor characteristics in congenic strains of RCS rats. LaVail MM Invest Ophthalmol Vis Sci 1981 May;20(5):671-5.
4. Congenic strains of RCS rats with inherited retinal dystrophy. LaVail MM, etal., J Hered 1975 Jul-Aug;66(4):242-4.
5. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These are tan-hooded, pink-eyed animals. 632096
strain_life_disease They have inherited retinal dystrophy as a result of genetic defect in retinal pigment epithelium. 632096
strain_life_disease Mutation in the Mertk is responsible for retinal degeneration where shed outer segments are phagocytosed by the retinal pigment epithelial (RPE) and metabolites recycled to the photoreceptors.  
strain_other When reared in the dark these have a greater accumulation of rhodopsin in the eyes. 632096

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-08-23 RCS/LavRrrc  royal college of surgeons rat  RCS/Lav  royal college of surgeons rat  Name/Symbol updated 68913 APPROVED

Database Acc Id Source(s)