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Strain: KZC/Tky

Symbol: KZC/Tky
Strain: KZC
Substrain: Tky
Full Name: Komeda Zucker Creeping rat
RGD ID: 1302714
Citation ID: RRID:RGD_1302714
Ontology ID: RS:0001338
Alleles: Reln
Previously known as: NBRP Rat No: 0028
Type: segregating_inbred
Source: National BioResource Project for the Rat in Japan
Origin: Komeda Zucker Creeping rat derived from a closed colony of the Zucker fatty rat by spontaniously mutation at Tokyo Medical College in 1983.
Genetic Markers: Hooded
Coat Color: Brown
Inbred Generations: F45
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Neurobiology


References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Rat neurological disease creeping is caused by a mutation in the reelin gene. Yokoi N, etal., Brain Res Mol Brain Res 2003 Apr 10;112(1-2):1-7.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease The animals exhibiting severe ataxia with staggering gait and tremor at about 14 days of age, and die around 4 weeks of age. The cerebellum of the mutants shows severe hypoplasia with the reduction of the molecular and granular layers and malposition of Purkinje cells in the white matter. 727518
strain_phys_biochem The abnormal pathological changes are also detected in the cerebrum, including the absence of a well-defined outer molecular layer, no typical lamination, and irregular cell arrangement in the hippocampus. 727518
strain_reproduction Maintained in heterozygous condition. 727518

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-07 KZC/Tky  Komeda Zucker Creeping rat  KZC/Tky  Komeda Zucker Creeping rat  Name updated 68913 APPROVED