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Summary
Annotation
RGD Manual Disease
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Mammalian Phenotype
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References - curated
Strain Registration
General
Strain: F344-
Atm
em1Kyo
Symbol:
F344-
Atm
em1Kyo
Strain:
F344-
Atm
em1
Substrain:
Kyo
Full Name:
ZFN-Atm rats
RGD ID:
12879400
Citation ID:
RRID:RGD_12879400
Ontology ID:
RS:0004408
Alleles:
Atm
em1Kyo
Also Known As:
NBRP No.0649; F344-Atmem1Kyo; F344-Atm^[em1Kyo]
Type:
mutant
Available Source:
National BioResource Project for the Rat in Japan
Origination:
National BioResource Project for the Rat in Japan
Description:
This rat strain was established by ZFN method targeting rat Atm gene (resulting in a 8-bp deletion of exon13). Background strain: F344/Stm.
Genetic Status:
Heterozygous
Coat Color:
Albino
Inbred Generations:
N1(2012)
Last Known Status:
Live Animals; Cryopreserved Sperm (as of 2017-04-18)
Research Usage
neurobiology
Position
Rat Assembly
Chr
Position (strand)
Source
JBrowse
GRCr8
8
62,724,939 - 62,829,040
RGD_MAPPER_PIPELINE
mRatBN7.2
8
53,828,741 - 53,932,773
RGD_MAPPER_PIPELINE
mRatBN7.2
Rnor_6.0
8
58,015,938 - 58,119,973
RGD_MAPPER_PIPELINE
Rnor6.0
Rnor_5.0
8
56,598,503 - 56,703,115
RGD_MAPPER_PIPELINE
Rnor5.0
RGSC_v3.4
8
56,894,746 - 56,996,565
RGD_MAPPER_PIPELINE
RGSC3.4
Annotation
Click to see Annotation Summary View
RGD Manual Disease Annotations
Click to see Annotation Summary View
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
F344-
Atm
em1Kyo
Rat
ataxia telangiectasia
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
disease of cellular proliferation
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
infertility
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
leukemia
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
lymphoma
IMP
12879399
RGD
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Phenotype Annotations
Click to see Annotation Summary View
Mammalian Phenotype
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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
F344-
Atm
em1Kyo
Rat
abnormal microglial cell activation
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
abnormal ovarian folliculogenesis
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
abnormal seminiferous tubule morphology
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
decreased microglial cell number
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
decreased motor neuron number
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
hindlimb paralysis
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
microgliosis
IMP
12879399
RGD
F344-
Atm
em1Kyo
Rat
oxidative stress
IMP
12879399
RGD
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Disease Annotations
Click to see Annotation Summary View
1 to 2 of 2 rows
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ataxia telangiectasia
(IMP)
disease of cellular proliferation
(IMP)
infertility
(IMP)
leukemia
(IMP)
lymphoma
(IMP)
1 to 2 of 2 rows
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Phenotype Annotations
Click to see Annotation Summary View
Mammalian Phenotype
1 to 3 of 3 rows
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abnormal microglial cell activation
(IMP)
abnormal ovarian folliculogenesis
(IMP)
abnormal seminiferous tubule morphology
(IMP)
decreased microglial cell number
(IMP)
decreased motor neuron number
(IMP)
hindlimb paralysis
(IMP)
microgliosis
(IMP)
oxidative stress
(IMP)
1 to 3 of 3 rows
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References
References - curated
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#
Reference Title
Reference Citation
1.
Strains registered by the National Bio Resource Project for the Rat in Japan
Personal Communication with NBRP
2.
A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.
Quek H, etal., Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371.
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Region
Additional Information