Strain Report - Rat Genome Database

Name: F344- Atm em1Kyo
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: F344-Atm^em1Kyo

Symbol:

F344-Atm^em1Kyo

Strain:

F344-Atm^em1

Substrain:

Kyo

Full Name:

ZFN-Atm rats

RGD ID:

12879400

Citation ID:

RRID:RGD_12879400

Ontology ID:

RS:0004408

Alleles:

Atm^em1Kyo

Previously known as:

NBRP No.0649; F344-Atmem1Kyo

Type:

mutant

Source:

National BioResource Project for the Rat in Japan

Origin:

This rat strain was established by ZFN method targeting rat Atm gene (resulting in a 8-bp deletion of exon13). Background strain: F344/Stm.

Genetic Status:

Heterozygous

Coat Color:

Albino

Inbred Generations:

N1(2012)

Last Known Status:

Live Animals; Cryopreserved Sperm (as of 2017-04-18)

Research Usage

neurobiology

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	53,828,741 - 53,932,773	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	8	58,015,938 - 58,119,973	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	8	56,598,503 - 56,703,115	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	8	56,894,746 - 56,996,565	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

ataxia telangiectasia (IMP)

disease of cellular proliferation (IMP)

infertility (IMP)

leukemia (IMP)

lymphoma (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal microglial cell activation (IMP)

abnormal ovarian folliculogenesis (IMP)

abnormal seminiferous tubule morphology (IMP)

decreased microglial cell number (IMP)

decreased motor neuron number (IMP)

hindlimb paralysis (IMP)

microgliosis (IMP)

oxidative stress (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
2.	A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype.	Quek H, etal., Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371.

Region

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: F344-Atmem1Kyo

Mammalian Phenotype

Strain: F344-Atm^em1Kyo