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Strain: LE-Fmr1em2Mcwi

Symbol: LE-Fmr1em2Mcwi
Strain: LE-Fmr1em2
Substrain: Mcwi
RGD ID: 11553873
Citation ID: RRID:RGD_11553873
Ontology ID: RS:0005323
Alleles: Fmr1em2Mcwi
Also Known As: LE-Fmr1em2Mcwi; LE-Fmr1^[em2Mcwi]
Type: mutant
Available Source: Contact MCW rat distribution at
Origination: Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center
Description: CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp insertion in exon 8 of the Fmr1 gene.
Coat Color: Albino/black hooded
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
Research Usage Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE)
Genotyping Protocol Download Genotyping Protocol
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X147,240,239 - 147,278,057RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X154,703,634 - 154,703,635RGD_MAPPER_PIPELINERnor6.0
RGSC_v3.4X154,756,031 - 154,793,782RGD_MAPPER_PIPELINERGSC3.4



References - curated
# Reference Title Reference Citation
1. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Leontiadis LJ, etal., Brain Sci. 2023 Nov 17;13(11):1598. doi: 10.3390/brainsci13111598.
2. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Leontiadis LJ, etal., Dev Neurosci. 2024 Feb 16. doi: 10.1159/000537879.
3. Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome. Leontiadis LJ, etal., Front Cell Neurosci. 2023 Dec 1;17:1296235. doi: 10.3389/fncel.2023.1296235. eCollection 2023.
4. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Miller EA, etal., Mol Psychiatry. 2020 Mar 6. pii: 10.1038/s41380-020-0703-y. doi: 10.1038/s41380-020-0703-y.
5. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Ntoulas G, etal., Transl Psychiatry. 2024 Feb 20;14(1):104. doi: 10.1038/s41398-024-02815-0.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Fmr1em2Mcwi-var1 chrX 154703634 154703635 AG GCA delins Rnor_6.0

Additional Information