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Strain Registration

Strain: LE-Fmr1em2Mcwi

Symbol: LE-Fmr1em2Mcwi
Strain: LE-Fmr1em2
Substrain: Mcwi
RGD ID: 11553873
Citation ID: RRID:RGD_11553873
Ontology ID: RS:0004246
Alleles: Fmr1em2Mcwi
Previously known as: LE-Fmr1em2Mcwi
Type: mutant
Source: Generated with support from the Simons Foundation Autism Research Initiative (SFARI ); MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu
Origin: CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp insertion in exon 8 of the Fmr1 gene.
Coat Color: Albino/black hooded
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
Research Usage Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE)
Genotyping Protocol Download Genotyping Protocol
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X147,240,239 - 147,278,057RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X154,684,924 - 154,722,369RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01150,408,220 - 150,445,658RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X154,756,031 - 154,793,782RGD_MAPPER_PIPELINERGSC3.4


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References

References - curated
# Reference Title Reference Citation
1. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Miller EA, etal., Mol Psychiatry. 2020 Mar 6. pii: 10.1038/s41380-020-0703-y. doi: 10.1038/s41380-020-0703-y.

Region


Additional Information