Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: LE-Fmr1em2Mcwi

Symbol: LE-Fmr1em2Mcwi
Strain: LE-Fmr1em2
Substrain: Mcwi
RGD ID: 11553873
Citation ID: RRID:RGD_11553873
Ontology ID: RS:0005323
Alleles: Fmr1em2Mcwi
Also Known As: LE-Fmr1em2Mcwi; LE-Fmr1^[em2Mcwi]
Type: mutant
Available Source: Contact MCW rat distribution at mcwcustomrats@mcw.edu
Origination: Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center
Description: CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp insertion in exon 8 of the Fmr1 gene.
Coat Color: Albino/black hooded
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
Research Usage Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE)
Genotyping Protocol Download Genotyping Protocol
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X147,240,239 - 147,278,057RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X154,703,634 - 154,703,635RGD_MAPPER_PIPELINERnor6.0
RGSC_v3.4X154,756,031 - 154,793,782RGD_MAPPER_PIPELINERGSC3.4


Highlights







References

References - curated
# Reference Title Reference Citation
1. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Leontiadis LJ, etal., Brain Sci. 2023 Nov 17;13(11):1598. doi: 10.3390/brainsci13111598.
2. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Leontiadis LJ, etal., Dev Neurosci. 2024 Feb 16. doi: 10.1159/000537879.
3. Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome. Leontiadis LJ, etal., Front Cell Neurosci. 2023 Dec 1;17:1296235. doi: 10.3389/fncel.2023.1296235. eCollection 2023.
4. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Miller EA, etal., Mol Psychiatry. 2020 Mar 6. pii: 10.1038/s41380-020-0703-y. doi: 10.1038/s41380-020-0703-y.
5. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Ntoulas G, etal., Transl Psychiatry. 2024 Feb 20;14(1):104. doi: 10.1038/s41398-024-02815-0.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Fmr1em2Mcwi-var1 chrX 154703634 154703635 AG GCA delins Rnor_6.0

Additional Information