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Strain: LE-Fmr1em2Mcwi

Symbol: LE-Fmr1em2Mcwi
Strain: LE-Fmr1em2
Substrain: Mcwi
RGD ID: 11553873
Citation ID: RRID:RGD_11553873
Ontology ID: RS:0005323
Alleles: Fmr1em2Mcwi
Also Known As: LE-Fmr1em2Mcwi; LE-Fmr1^[em2Mcwi]
Type: mutant
Available Source: Autism Rat Model Resource, Contact MCW rat distribution at mcwcustomrats@mcw.edu
Origination: Generated with support from the Simons Foundation Autism Research Initiative (SFARI); MCW Gene Editing Rat Resource Center
Description: CRISPR/Cas9 system was used to introduce a mutation in the Fmr1 gene of Crl:LE rat embryos. The resulting mutation is a 2-bp insertion in exon 8 of the Fmr1 gene.
Coat Color: Albino/black hooded
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2021-11-03)
Research Usage Autism, ADHD, Developmental delay, Intellectual disability, Epilepsy (from SFARI GENE)
Genotyping Protocol Download Genotyping Protocol
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X152,284,857 - 152,322,686RGD_MAPPER_PIPELINE
mRatBN7.2X147,240,239 - 147,278,057RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X154,703,634 - 154,703,635RGD_MAPPER_PIPELINERnor6.0
RGSC_v3.4X154,756,031 - 154,793,782RGD_MAPPER_PIPELINERGSC3.4


Highlights







1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
LE-Fmr1em2McwiRatabnormal prepulse inhibition no_associationIAGP 35668860compared to wild type controlsRGD 
LE-Fmr1em2McwiRatabnormal prepulse inhibition sexual_dimorphismIAGP 35668860in wild type controlsRGD 
LE-Fmr1em2McwiRatabnormal spike wave discharge  IMP 401976423compared to wild type controlsRGD 
LE-Fmr1em2McwiRatabnormal startle reflex no_associationIAGP 35668860compared to wild type controlsRGD 
LE-Fmr1em2McwiRatabnormal startle reflex sexual_dimorphismIAGP 35668860in wild type controlsRGD 
LE-Fmr1em2McwiRathyperactivity  IMP 401976422compared to wild type controlsRGD 
LE-Fmr1em2McwiRatimpaired short-term object recognition memory  IMP 401976422compared to wild type controlsRGD 
LE-Fmr1em2McwiRatimpaired spatial learning  IMP 401976422compared to wild type controlsRGD 
LE-Fmr1em2McwiRatincreased paired-pulse inhibition  IMP 401976422compared to wild type controlsRGD 
LE-Fmr1em2McwiRatincreased paired-pulse inhibition  IMP 401976423compared to wild type controlsRGD 
1 to 10 of 10 rows

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Reference Title
Reference Citation
1. Mapping the landscape of social behavior. Klibaite U, etal., bioRxiv [Preprint]. 2024 Sep 27:2024.09.27.615451. doi: 10.1101/2024.09.27.615451.
2. Increased Inhibition May Contribute to Maintaining Normal Network Function in the Ventral Hippocampus of a Fmr1-Targeted Transgenic Rat Model of Fragile X Syndrome. Leontiadis LJ, etal., Brain Sci. 2023 Nov 17;13(11):1598. doi: 10.3390/brainsci13111598.
3. Septotemporal variation of information processing in the hippocampus of Fmr1 KO rat. Leontiadis LJ, etal., Dev Neurosci. 2024 Feb 16. doi: 10.1159/000537879.
4. Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome. Leontiadis LJ, etal., Front Cell Neurosci. 2023 Dec 1;17:1296235. doi: 10.3389/fncel.2023.1296235. eCollection 2023.
5. Robust and replicable measurement for prepulse inhibition of the acoustic startle response. Miller EA, etal., Mol Psychiatry. 2020 Mar 6. pii: 10.1038/s41380-020-0703-y. doi: 10.1038/s41380-020-0703-y.
6. Multi-level profiling of the Fmr1 KO rat unveils altered behavioral traits along with aberrant glutamatergic function. Ntoulas G, etal., Transl Psychiatry. 2024 Feb 20;14(1):104. doi: 10.1038/s41398-024-02815-0.
7. Region-Related Differences in Short-Term Synaptic Plasticity and Synaptotagmin-7 in the Male and Female Hippocampus of a Rat Model of Fragile X Syndrome. Tsotsokou G, etal., Int J Mol Sci. 2024 Jun 26;25(13):6975. doi: 10.3390/ijms25136975.


Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Fmr1em2Mcwi-var1 chrX 154703634 154703635 AG GCA delins Rnor_6.0