RGD Reference Report - Inhibition of the binding of low density lipoproteins to liver membrane receptors by rat serum phosphorylcholine binding protein. - Rat Genome Database

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Inhibition of the binding of low density lipoproteins to liver membrane receptors by rat serum phosphorylcholine binding protein.

Authors: Saxena, U  Nagpurkar, A  Mookerjea, S 
Citation: Saxena U, etal., Biochem Biophys Res Commun. 1986 Nov 26;141(1):151-7.
RGD ID: 9586005
Pubmed: PMID:3800992   (View Abstract at PubMed)

Rat serum phosphorylcholine binding protein (PCBP) is characterized by its Ca2+ dependent property to bind phosphorylcholine ligand. PCBP immobilized on sepharose has been shown to selectively bind human plasma apo B and E containing lipoproteins. The present report describes an inhibitory effect of PCBP on the binding of human 125I-LDL to LDL receptors on estradiol treated rat liver membranes. Pre-incubation of liver membranes with PCBP did not affect the binding of 125I-LDL to the membranes. Gel filtration analysis of the incubation products from the LDL-receptor assay showed a concentration dependent binding of 125I-PCBP to LDL. The inhibitory effect of PCBP is likely due to the formation of LDL-PCBP complex and not due to the binding of PCBP to the LDL receptor site.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CrpRatlow-density lipoprotein particle binding  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crp  (C-reactive protein)


Additional Information