RGD Reference Report - Polycomb group proteins are essential for spinal cord development. - Rat Genome Database

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Polycomb group proteins are essential for spinal cord development.

Authors: Wang, C  Zhao, JJ  Lu, CL  Han, XD  An, LS  Ma, X 
Citation: Wang C, etal., Front Biosci (Landmark Ed). 2010 Jun 1;15:1018-22.
RGD ID: 9491842
Pubmed: PMID:20515739   (View Abstract at PubMed)

Birth defects are the leading cause of infantile mortality, followed by neural tube defects (NTD) and congenital heart defects. Spina bifida and anencephaly are among the most common forms of NTD. NTD etiologies are complex, and are associated with both genetic and environmental factors. Polycomb group proteins are essential for vertebrate development; therefore, the purpose of this study was to determine the role of PcGs in spinal cord morphogenesis in normal and all-trans-retinoic acid (RA)-treated fetal rat models of spina bifida. Pregnant rats were gavage-fed RA, resulting in fetal NTD, and embryos were obtained on day 15.5, 17.5, and 19.5. Western blot and immunohistochemistry were used to reveal PcGs expression in the normal and RA-treated E15.5-19.5 rat sacral cords. Western blot and immunohistochemistry revealed decreased EED, RNF2, SUZ12, and H3K27me3 expression in the normal, E15.5-19.5, rat sacral cords. In addition, the spinal cord of RA-treated rats during embryonic development exhibited altered PcGs protein expression. Administration of excess RA results in NTD. Our results suggest that the Polycomb proteins may be involved in spinal cord development.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
RNF2Humanspina bifida  ISORnf2 (Rattus norvegicus) RGD 
Rnf2Ratspina bifida  IEP  RGD 
Rnf2Mousespina bifida  ISORnf2 (Rattus norvegicus) RGD 
SUZ12Humanspina bifida  ISOSuz12 (Rattus norvegicus) RGD 
Suz12Ratspina bifida  IEP  RGD 
Suz12Mousespina bifida  ISOSuz12 (Rattus norvegicus) RGD 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Rnf2Ratresponse to retinoic acid  IEP  RGD 
Suz12Ratresponse to retinoic acid  IEP  RGD 
EedRatspinal cord development  IEP  RGD 
Rnf2Ratspinal cord development  IEP  RGD 
Suz12Ratspinal cord development  IEP  RGD 


Genes (Rattus norvegicus)
Eed  (embryonic ectoderm development) Rnf2  (ring finger protein 2) Suz12  (SUZ12 polycomb repressive complex 2 subunit)

Genes (Mus musculus)
Rnf2  (ring finger protein 2) Suz12  (SUZ12 polycomb repressive complex 2 subunit)

Genes (Homo sapiens)
RNF2  (ring finger protein 2) SUZ12  (SUZ12 polycomb repressive complex 2 subunit)