RGD Reference Report - SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. - Rat Genome Database

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SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.

Authors: Kalashnikova, E  Lorca, RA  Kaur, I  Barisone, GA  Li, B  Ishimaru, T  Trimmer, JS  Mohapatra, DP  Diaz, E 
Citation: Kalashnikova E, etal., Neuron. 2010 Jan 14;65(1):80-93. doi: 10.1016/j.neuron.2009.12.021.
RGD ID: 8554654
Pubmed: PMID:20152115   (View Abstract at PubMed)
PMCID: PMC2822728   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2009.12.021   (Journal Full-text)

During development of the central nervous system, precise synaptic connections between presynaptic and postsynaptic neurons are formed. While significant progress has been made in our understanding of AMPA receptor trafficking during synaptic plasticity, less is known about the molecules that recruit AMPA receptors to nascent synapses during synaptogenesis. Here we identify a type II transmembrane protein (SynDIG1) that regulates AMPA receptor content at developing synapses in dissociated rat hippocampal neurons. SynDIG1 colocalizes with AMPA receptors at synapses and at extrasynaptic sites and associates with AMPA receptors in heterologous cells and brain. Altered levels of SynDIG1 in cultured neurons result in striking changes in excitatory synapse number and function. SynDIG1-mediated synapse development is dependent on association with AMPA receptors via its extracellular C terminus. Intriguingly, SynDIG1 content in dendritic spines is regulated by neuronal activity. Altogether, we define SynDIG1 as an activity-regulated transmembrane protein that regulates excitatory synapse development.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Syndig1Ratpositive regulation of synapse assembly involved_inIMP PMID:20152115UniProt 
Syndig1Ratregulation of postsynapse assembly involved_inEXP PMID:20152115SynGO 
Syndig1Ratregulation of postsynapse assembly involved_inIDA PMID:20152115SynGO 
Syndig1Ratregulation of postsynapse assembly involved_inIMP PMID:20152115SynGO 
Syndig1Ratsynaptic vesicle clustering involved_inIDA PMID:20152115UniProt 

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Syndig1Ratcell body located_inIDA PMID:20152115UniProt 
Syndig1Ratdendritic shaft located_inIDA PMID:20152115UniProt 
Syndig1Ratdendritic spine located_inIDA PMID:20152115UniProt 
Syndig1Ratexcitatory synapse located_inIDA PMID:20152115UniProt 
Syndig1Ratglutamatergic synapse is_active_inEXP PMID:20152115SynGO 
Syndig1Ratglutamatergic synapse is_active_inIDA PMID:20152115SynGO 
Syndig1Ratglutamatergic synapse is_active_inIEP PMID:20152115SynGO 
Syndig1Ratglutamatergic synapse is_active_inIMP PMID:20152115SynGO 
Syndig1Ratpostsynaptic density membrane is_active_inIDA PMID:20152115SynGO 
Syndig1Ratpostsynaptic density membrane is_active_inIEP PMID:20152115SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Syndig1  (synapse differentiation inducing 1)


Additional Information