RGD Reference Report - A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. - Rat Genome Database

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A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.

Authors: Kang, J  Shi, Y  Xiang, B  Qu, B  Su, W  Zhu, M  Zhang, M  Bao, G  Wang, F  Zhang, X  Yang, R  Fan, F  Chen, X  Pei, G  Ma, L 
Citation: Kang J, etal., Cell. 2005 Dec 2;123(5):833-47.
RGD ID: 8554401
Pubmed: PMID:16325578   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cell.2005.09.011   (Journal Full-text)

Chromatin modification is considered to be a fundamental mechanism of regulating gene expression to generate coordinated responses to environmental changes, however, whether it could be directly regulated by signals mediated by G protein-coupled receptors (GPCRs), the largest surface receptor family, is not known. Here, we show that stimulation of delta-opioid receptor, a member of the GPCR family, induces nuclear translocation of beta-arrestin 1 (betaarr1), which was previously known as a cytosolic regulator and scaffold of GPCR signaling. In response to receptor activation, betaarr1 translocates to the nucleus and is selectively enriched at specific promoters such as that of p27 and c-fos, where it facilitates the recruitment of histone acetyltransferase p300, resulting in enhanced local histone H4 acetylation and transcription of these genes. Our results reveal a novel function of betaarr1 as a cytoplasm-nucleus messenger in GPCR signaling and elucidate an epigenetic mechanism for direct GPCR signaling from cell membrane to the nucleus through signal-dependent histone modification.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Arrb1Ratpositive regulation of transcription by RNA polymerase II involved_inIDA PMID:16325578UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Arrb1  (arrestin, beta 1)


Additional Information