RGD Reference Report - Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product. - Rat Genome Database

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Serine 62 is a phosphorylation site in folliculin, the Birt-Hogg-Dube gene product.

Authors: Wang, L  Kobayashi, T  Piao, X  Shiono, M  Takagi, Y  Mineki, R  Taka, H  Zhang, D  Abe, M  Sun, G  Hagiwara, Y  Okimoto, K  Matsumoto, I  Kouchi, M  Hino, O 
Citation: Wang L, etal., FEBS Lett. 2010 Jan 4;584(1):39-43. doi: 10.1016/j.febslet.2009.11.033. Epub .
RGD ID: 8553849
Pubmed: PMID:19914239   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2009.11.033   (Journal Full-text)

Recently, it was reported that the product of Birt-Hogg-Dube syndrome gene (folliculin, FLCN) is directly phosphorylated by 5'-AMP-activated protein kinase (AMPK). In this study, we identified serine 62 (Ser62) as a phosphorylation site in FLCN and generated an anti-phospho-Ser62-FLCN antibody. Our analysis suggests that Ser62 phosphorylation is indirectly up-regulated by AMPK and that another residue is directly phosphorylated by AMPK. By binding with FLCN-interacting proteins (FNIP1 and FNIP2/FNIPL), Ser62 phosphorylation is increased. A phospho-mimic mutation at Ser62 enhanced the formation of the FLCN-AMPK complex. These results suggest that function(s) of FLCN-AMPK-FNIP complex is regulated by Ser62 phosphorylation.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

Objects Annotated

Genes (Rattus norvegicus)
Flcn  (folliculin)
Prkaa1  (protein kinase AMP-activated catalytic subunit alpha 1)


Additional Information