RGD Reference Report - Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation. - Rat Genome Database

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Expression of phospho-Elk-1 in rat gut after the whole body gamma irradiation.

Authors: Driak, D  Osterreicher, J  Rehakova, Z  Vilasova, Z  Vavrova, J 
Citation: Driak D, etal., Physiol Res. 2008;57(5):753-9. Epub 2007 Oct 11.
RGD ID: 7488908
Pubmed: PMID:17949253   (View Abstract at PubMed)

Gastrointestinal form is the second stage of acute radiation syndrome (ARS) with a threshold dose of 8 Gy in man. It represents an absolutely lethal clinical-pathological unit, necro-hemorrhagic enteritis and proctocolitis, with unknown causal therapy. Elk-1 is a protein acting as a transcription factor activating specified genes. The purpose of our study was to examine the expression of phospho-Elk-1 in irradiated jejunum and transversal colon of rats with radiation-induced enterocolitis and to assess the importance of this transcriptional factor as a biodosimetric marker of radiation-induced enteropathy. The laboratory rats were randomly divided into 21 groups, 10 animals per group, and irradiated with whole body gamma-irradiation of 1, 5, 10, 15, and 20 Gy. Samples of jejunum and transversal colon were taken 24, 48, 72, and 96 hours later, immunohisto-chemically stained, and the phospho-Elk-1 expression was examined using computer image analysis. A group of 10 sham-irradiated animals was used as control. Significantly increased expression of phospho-Elk-1 in rat jejunum has been found in all time intervals after irradiation by sublethal doses of 1 and 5 Gy, whereas after the irradiation by lethal doses, the expression of phospho-Elk-1 in rat jejunum varied considerably. Significantly increased expression of phospho-Elk-1 in transversal colon has also been found in the first days after irradiation by sublethal doses of 1 and 5 Gy. After irradiation by lethal doses, there was no uniform pattern of the changes in the expression of phospho-Elk-1 in rat transversal colon. The detection of phospho-Elk-1 might be considered as a suitable and very sensitive biodosimetric marker of radiation-induced injury of small and large intestine. According to our knowledge, this is the first study on the phospho-Elk-1 expression in irradiated jejunum and transversal colon in the rat.




Biological Process

  
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Original Reference(s)
Elk1Ratcellular response to gamma radiation  IDA  RGD 


Genes (Rattus norvegicus)
Elk1  (ETS transcription factor ELK1)