RGD Reference Report - Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts. - Rat Genome Database

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Antigens of activated rat T lymphocytes including a molecule of 50,000 Mr detected only on CD4 positive T blasts.

Authors: Paterson, DJ  Jefferies, WA  Green, JR  Brandon, MR  Corthesy, P  Puklavec, M  Williams, AF 
Citation: Paterson DJ, etal., Mol Immunol 1987 Dec;24(12):1281-90.
RGD ID: 730097
Pubmed: PMID:2828930   (View Abstract at PubMed)

Mouse monoclonal antibodies (MAbs) have been prepared against rat T cell blasts. One MAb called MRC OX-40 recognized an antigen that differed from any previously described in that its expression was detected only on T blasts that also expressed the CD4 antigen. The OX-40 MAb did not detect an activation determinant of CD2 or CD4 molecules but recognized a distinct chain of mol. wt 50,000. The OX-40 MAb augmented T cell proliferation at late stages on in vitro responses. Other MAbs without obvious counterparts in other species were MRC OX-48 and MRC OX-49,50 which recognized cell surface molecules of mol. wts of about 95,000 and 90,000, respectively. The OX-48 antigen was not expressed on resting lymphocytes but was found on a subset of T and B blasts and also on other leucocytes. The OX-49,50 antigen was found on most haemopoietic cells but was expressed at greatly increased levels after lymphocyte activation and this was also the case for MRC OX-47 antigen which is of unknown Mr. The MRC OX-39 MAb was found to bind the rat IL-2 receptor; expression of this antigen was detected on thymic dendritic cells as well as on T blasts. The phenotype of rat T blasts compared to resting cells was also examined and changes in expression of L-CA, Thy-1, OX-2 and CD8 antigens were seen in addition to the changes found with the above MAbs.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tnfrsf4RatT cell proliferation involved_inIMP PMID:2828930BHF-UCL 

Cellular Component

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Tnfrsf4Ratcell surface located_inIMP PMID:2828930BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Tnfrsf4  (TNF receptor superfamily member 4)

Objects referenced in this article
Gene TNFRSF4 TNF receptor superfamily member 4 Homo sapiens

Additional Information