RGD Reference Report - Identification of a novel gene encoding an insulin-responsive glucose transporter protein. - Rat Genome Database

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Identification of a novel gene encoding an insulin-responsive glucose transporter protein.

Authors: Birnbaum, MJ 
Citation: Birnbaum MJ Cell 1989 Apr 21;57(2):305-15.
RGD ID: 729967
Pubmed: PMID:2649253   (View Abstract at PubMed)

Insulin, rapidly and independently of new protein synthesis, stimulates glucose transport in sensitive target tissues. A cDNA has been cloned from a skeletal muscle library that encodes a novel glucose transporter protein exhibiting the following properties of an insulin-regulated hexose carrier protein: it is expressed exclusively in adipose tissue, skeletal muscle and heart, the principal organs with insulin-responsive glucose transport; RNA transcribed from the muscle cDNA, when expressed in Xenopus oocytes, encodes a protein capable of cytochalasin B inhibitable 2-deoxyglucose transport; and treatment of isolated rat adipocytes with insulin effects a redistribution of "muscle" transports from low density microsomes to the plasma membrane to an extent comparable to the activation of glucose transport.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc2a4RatD-glucose transmembrane transport involved_inIDA PMID:2649253UniProt 
Slc2a4Ratglucose import in response to insulin stimulus involved_inIDA PMID:2649253UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Slc2a4RatD-glucose transmembrane transporter activity enablesIDA PMID:2649253UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Slc2a4  (solute carrier family 2 member 4)


Additional Information