RGD Reference Report - MacroH2A, a core histone containing a large nonhistone region. - Rat Genome Database

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MacroH2A, a core histone containing a large nonhistone region.

Authors: Pehrson, JR  Fried, VA 
Citation: Pehrson JR and Fried VA, Science 1992 Sep 4;257(5075):1398-400.
RGD ID: 728409
Pubmed: PMID:1529340   (View Abstract at PubMed)

A histone, macroH2A, nearly three times the size of conventional H2A histone, was found in rat liver nucleosomes. Its N-terminal third is 64 percent identical to a full-length mouse H2A. However, it also contains a large nonhistone region. This region has a segment that resembles a leucine zipper, a structure known to be involved in dimerization of some transcription factors. Nucleosomes containing macroH2A may have novel functions, possibly involving interactions with other nuclear proteins.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Macroh2a1Ratnucleosome  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Macroh2a1  (macroH2A.1 histone)


Additional Information