RGD Reference Report - Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system. - Rat Genome Database

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Catalase prevents maternal diabetes-induced perinatal programming via the Nrf2-HO-1 defense system.

Authors: Chang, SY  Chen, YW  Zhao, XP  Chenier, I  Tran, S  Sauve, A  Ingelfinger, JR  Zhang, SL 
Citation: Chang SY, etal., Diabetes. 2012 Oct;61(10):2565-74. Epub 2012 Jun 25.
RGD ID: 7206853
Pubmed: PMID:22733796   (View Abstract at PubMed)
PMCID: PMC3447903   (View Article at PubMed Central)
DOI: DOI:10.2337/db12-0248   (Journal Full-text)

We investigated whether overexpression of catalase (CAT) in renal proximal tubular cells (RPTCs) could prevent the programming of hypertension and kidney disease in the offspring of dams with maternal diabetes. Male offspring of nondiabetic and diabetic dams from two transgenic (Tg) lines (Hoxb7-green fluorescent protein [GFP]-Tg [controls] and Hoxb7/CAT-GFP-Tg, which overexpress CAT in RPTCs) were studied from the prenatal period into adulthood. Nephrogenesis, systolic blood pressure, renal hyperfiltration, kidney injury, and reactive oxygen species (ROS) generation were assessed. Gene expression of transforming growth factor-beta1 (TGF-beta1), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and heme oxygenase-1 (HO-1) was tested in both in vitro and in vivo studies. Renal dysmorphogenesis was observed in offspring of Hoxb7-GFP-Tg dams with severe maternal diabetes; the affected male offspring displayed higher renal ROS generation and developed hypertension and renal hyperfiltration as well as renal injury with heightened TGF-beta1 expression in adulthood. These changes were ameliorated in male offspring of diabetic Hoxb7/CAT-GFP-Tg dams via the Nrf2-HO-1 defense system. CAT promoted Nrf2 nuclear translocation and HO-1 gene expression, seen in both in vitro and in vivo studies. In conclusion, CAT overexpression in the RPTCs ameliorated maternal diabetes-induced perinatal programming, mediated, at least in part, by triggering the Nrf2-HO-1 defense system.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CATHumanRenoprival Hypertension  ISOCat (Rattus norvegicus) RGD 
CatRatRenoprival Hypertension  IMP  RGD 
CatMouseRenoprival Hypertension  ISOCat (Rattus norvegicus) RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CatRatkidney development  IMP  RGD 
CatRatureteric bud development  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cat  (catalase)

Genes (Mus musculus)
Cat  (catalase)

Genes (Homo sapiens)
CAT  (catalase)


Additional Information