RGD Reference Report - Kidney expression of RhoA, TGF-beta1, and fibronectin in human IgA nephropathy. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Kidney expression of RhoA, TGF-beta1, and fibronectin in human IgA nephropathy.

Authors: Mattii, L  Segnani, C  Cupisti, A  D'Alessandro, D  Moscato, S  Meola, M  Barsotti, G  Marino, M  Bianchi, F  Dolfi, A  Bernardini, N 
Citation: Mattii L, etal., Nephron Exp Nephrol. 2005;101(1):e16-23. Epub 2005 May 27.
RGD ID: 7206844
Pubmed: PMID:15925904   (View Abstract at PubMed)
DOI: DOI:10.1159/000086035   (Journal Full-text)

BACKGROUND: The Rho/transforming growth factor-beta (TGF-beta) system plays a crucial role in the progression of renal damage due to stimulation of extracellular matrix molecule deposition. In fact, the in vitro TGF-beta-mediated production of fibronectin, one of the major TGF-beta-regulated extracellular components, has recently been correlated with Rho protein signalling molecules. Although a close relationship between increased renal tissue levels of TGF-beta1 and fibronectin has been reported in IgA nephropathy, no data are available on renal tissue expression of Rho proteins. METHODS: This study was designed to assess in IgA nephropathy patients the kidney tissue immunohistochemical expression of RhoA, TGF-beta1, and fibronectin, and the rate of immunoreactivity for each antigen by image analysis. RESULTS: An increase in RhoA, TGF-beta1, and fibronectin expression was detected in tubulointerstitium and in glomeruli of IgA nephropathy compared to normal kidneys; in particular, RhoA was found also in proximal tubules, unlike control kidneys and mainly at the cell boundary level, which is in keeping with its activated form. The image analysis confirmed that the kidney tissue levels of RhoA, TGF-beta1, and fibronectin were significantly enhanced in the patients. CONCLUSION: This study suggests that RhoA may represent a key molecule in the signalling transduction pathway of profibrotic signals in IgA nephropathy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FN1HumanIgA glomerulonephritis  IEP protein:increased expression:kidneyRGD 
Fn1RatIgA glomerulonephritis  ISOFN1 (Homo sapiens)protein:increased expression:kidneyRGD 
Fn1MouseIgA glomerulonephritis  ISOFN1 (Homo sapiens)protein:increased expression:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fn1  (fibronectin 1)

Genes (Mus musculus)
Fn1  (fibronectin 1)

Genes (Homo sapiens)
FN1  (fibronectin 1)


Additional Information