RGD Reference Report - Smad8 mediates the signaling of the ALK-2 receptor serine kinase. - Rat Genome Database

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Smad8 mediates the signaling of the ALK-2 receptor serine kinase.

Authors: Chen, Y  Bhushan, A  Vale, W 
Citation: Chen Y, etal., Proc Natl Acad Sci U S A 1997 Nov 25;94(24):12938-43.
RGD ID: 70780
Pubmed: PMID:9371779   (View Abstract at PubMed)
PMCID: PMC24242   (View Article at PubMed Central)

Smad proteins are critical intracellular mediators of signaling by growth and differentiation factors of the transforming growth factor beta superfamily. We have isolated a member of the Smad family, Smad8, from a rat brain cDNA library and biochemically and functionally characterized its ability to transduce signals from serine kinase receptors. In Xenopus embryo, Smad8 is able to transcriptionally activate a subset of mesoderm target genes similar to those induced by the receptor serine kinase, activin receptor-like kinase (ALK)-2. Smad8 can be specifically phosphorylated by a constitutively active ALK-2 but not the related receptor serine kinase, ALK-4. In response to signaling from ALK-2, Smad8 associates with a common regulatory molecule, Smad4, and this association leads to a synergistic effect on gene transcription. Furthermore, Smad8 is able to rescue the expression of mesoderm genes blocked by truncated ALK-2 in the embryo. These results indicate that Smad8 can function as a downstream signaling mediator of ALK-2.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Smad9Ratpositive regulation of DNA-templated transcription  IDA  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Smad9Ratprotein binding  IPISMAD4 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Smad9  (SMAD family member 9)


Additional Information