RGD Reference Report - Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II. - Rat Genome Database

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Identification of syntaxin-1A sites of phosphorylation by casein kinase I and casein kinase II.

Authors: Dubois, T  Kerai, P  Learmonth, M  Cronshaw, A  Aitken, A 
Citation: Dubois T, etal., Eur J Biochem 2002 Feb;269(3):909-14.
RGD ID: 70601
Pubmed: PMID:11846792   (View Abstract at PubMed)

Casein kinases I (CKI) are serine/threonine protein kinases widely expressed in a range of eukaryotes including yeast, mammals and plants. They have been shown to play a role in diverse physiological events including membrane trafficking. CKI alpha is associated with synaptic vesicles and phosphorylates some synaptic vesicle associated proteins including SV2. In this report, we show that syntaxin-1A is phosphorylated in vitro by CKI on Thr21. Casein kinase II (CKII) has been shown previously to phosphorylate syntaxin-1A in vitro and we have identified Ser14 as the CKII phosphorylation site, which is known to be phosphorylated in vivo. As syntaxin-1A plays a key role in the regulation of neurotransmitter release by forming part of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex, we propose that CKI may play a role in synaptic vesicle exocytosis.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Stx1aRatneurotransmitter transport  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Stx1a  (syntaxin 1A)


Additional Information