RGD Reference Report - The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). - Rat Genome Database

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The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7).

Authors: Surprenant, A  Rassendren, F  Kawashima, E  North, RA  Buell, G 
Citation: Surprenant A, etal., Science 1996 May 3;272(5262):735-8.
RGD ID: 69918
Pubmed: PMID:8614837   (View Abstract at PubMed)

The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Other ATP-gated channels, the P2X receptors, are permeable only to small cations. Here, an ATP receptor, the P2X7 receptor, was cloned from rat brain and exhibited both these properties. This protein is homologous to other P2X receptors but has a unique carboxyl-terminal domain that was required for the lytic actions of ATP. Thus, the P2X7 (or P2Z) receptor is a bifunctional molecule that could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
P2rx7Ratextrinsic apoptotic signaling pathway involved_inIDA PMID:8614837BHF-UCL 
P2rx7Ratmembrane depolarization involved_inIDA PMID:8614837BHF-UCL 
P2rx7Ratresponse to ATP involved_inIDA PMID:8614837BHF-UCL 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
P2rx7Ratextracellularly ATP-gated monoatomic cation channel activity enablesIDA PMID:8614837BHF-UCL 
P2rx7Ratpurinergic nucleotide receptor activity enablesIDA PMID:8614837BHF-UCL 

Objects Annotated

Genes (Rattus norvegicus)
P2rx7  (purinergic receptor P2X 7)


Additional Information