RGD Reference Report - IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. - Rat Genome Database

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IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.

Authors: Sonderegger, I  Kisielow, J  Meier, R  King, C  Kopf, M 
Citation: Sonderegger I, etal., Eur J Immunol. 2008 Jul;38(7):1833-8.
RGD ID: 6892939
Pubmed: PMID:18546146   (View Abstract at PubMed)
DOI: DOI:10.1002/eji.200838511   (Journal Full-text)

Th17 cells have been recognized as the central effectors in organ-related autoimmune diseases. IL-6 is a key factor that reciprocally regulates Th17 and Foxp3(+) Treg differentiation by inhibition of TGF-beta induced Foxp3 and induction of RORgammat, a Th17 lineage-specific transcription factor. Recently IL-21 has been suggested to induce RORgammat and Th17 development in the absence of IL-6. However, the relevance of IL-21 for Th17-dependent inflammatory responses in vivo remains unclear. In this study, we demonstrate that differentiation of IL-17-producing CD4 T cells, their recruitment to inflamed organs, and the development of autoimmune disease was not affected in il21R(-/-) and il21(-/-) mice in models of myelin oligodendrocyte glycoprotein-induced autoimmune encephalitis and autoimmune myocarditis. IL-6 induced Th17 differentiation independent of and much more potently than IL-21 in vitro. These data suggest that IL-6 is sufficient to drive Th17 development and associated autoimmunity in vivo in the absence of IL-21 or IL-21R.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL21RHumanExperimental Autoimmune Encephalomyelitis no_associationISORDG:1312688 RGD 
Il21rRatExperimental Autoimmune Encephalomyelitis no_associationISORDG:1312688 RGD 
Il21rMouseExperimental Autoimmune Encephalomyelitis no_associationIMP  RGD 
IL21RHumanmyocarditis no_associationISORDG:1312688 RGD 
Il21rRatmyocarditis no_associationISORDG:1312688 RGD 
Il21rMousemyocarditis no_associationIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il21r  (interleukin 21 receptor)

Genes (Mus musculus)
Il21r  (interleukin 21 receptor)

Genes (Homo sapiens)
IL21R  (interleukin 21 receptor)


Additional Information