RGD Reference Report - Transient receptor potential channels regulate myogenic tone of resistance arteries. - Rat Genome Database

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Transient receptor potential channels regulate myogenic tone of resistance arteries.

Authors: Welsh, DG  Morielli, AD  Nelson, MT  Brayden, JE 
Citation: Welsh DG, etal., Circ Res 2002 Feb 22;90(3):248-50.
RGD ID: 634441
Pubmed: PMID:11861411   (View Abstract at PubMed)

Elevation of intravascular pressure causes depolarization and constriction (myogenic tone) of small arteries and arterioles, and this response is a key element in blood flow regulation. However, the nature of pressure-induced depolarization has remained elusive. In the present study, we provide evidence that a transient receptor potential channel (TRPC6) homologue has a major role in this depolarizing response to pressure. Antisense oligodeoxynucleotides to TRPC6 decreased TRPC6 protein expression and greatly attenuated arterial smooth muscle depolarization and constriction caused by elevated pressure in intact cerebral arteries. Suppressing the expression of this channel protein also reduced the current density of a major cation current in resistance artery smooth muscle cells. We propose that TRPC6 channels play an essential role in regulation of myogenic tone.



Gene Trpc6 transient receptor potential cation channel, subfamily C, member 6 Rattus norvegicus