RGD Reference Report - IFN-gamma induces transglutaminase 2 expression in rat small intestinal cells. - Rat Genome Database

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IFN-gamma induces transglutaminase 2 expression in rat small intestinal cells.

Authors: Kim, SY  Jeong, EJ  Steinert, PM 
Citation: Kim SY, etal., J Interferon Cytokine Res 2002 Jun;22(6):677-82.
RGD ID: 634392
Pubmed: PMID:12162878   (View Abstract at PubMed)
DOI: DOI:10.1089/10799900260100169   (Journal Full-text)

Transglutaminase 2 (tissue transglutaminase, TGase 2) was recently identified as an endomysial autoantigen in celiac disease (CD). Identification of how TGase 2 expression is increased may allow a better understanding of this autoimmune disease. Certain inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta), and the Th type I cytokine interferon-gamma (INF-gamma) are abundant in CD. We have investigated whether these play a role in the regulation of TGase 2 expression in a model rat small intestinal epithelial cell line (IEC-6). After treatment for 24 h, TNF-alpha did not significantly alter TGase 2 mRNA or activity, but TGF-beta decreased mRNA and activity by 4-5-fold. IFN-gamma increased mRNA and TGase 2 activity by about 2-fold in 24 h and 5-fold by 5 days. Our new data suggest that increased TGase 2 expression in the upper small intestine of CD patients may be due to increased IFN-gamma expression, loss of TGF-beta signaling, or both.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IfngRatcytokine activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ifng  (interferon gamma)

Objects referenced in this article
Gene Tgm2 transglutaminase 2 Rattus norvegicus

Additional Information