RGD Reference Report - PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein. - Rat Genome Database

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PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein.

Authors: Yap, CC  Muto, Y  Kishida, H  Hashikawa, T  Yano, R 
Citation: Yap CC, etal., Biochem Biophys Res Commun 2003 Feb 21;301(4):1122-8.
RGD ID: 632941
Pubmed: PMID:12589829   (View Abstract at PubMed)

Inside cells, membrane proteins are localized at particular surface domains to perform their precise functions. Various kinds of PDZ domain proteins have been shown to play important roles in the intracellular trafficking and anchoring of membrane proteins. In this study, we show that delta2 glutamate receptor is interacting with S-SCAM/MAGI-2, a PDZ domain protein localized in the perinuclear region and postsynaptic sites of cerebellar Purkinje cells. The binding is regulated by PKC (protein kinase-C) mediated phosphorylation of the receptor with a unique repetitive structure in S-SCAM/MAGI-2. Co-expression of both proteins resulted in drastic changes of the receptor localization in COS7 cells. These results show a novel regulatory mechanism for the binding of PDZ domain proteins and suggest that the interaction between delta2 receptor and S-SCAM/MAGI-2 may be important for intracellular trafficking of the receptor.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Magi2Ratperinuclear region of cytoplasm located_inIDA PMID:12589829UniProt 
Magi2Ratpostsynaptic density located_inIDA PMID:12589829UniProt 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Grid2RatPDZ domain binding enablesIPIUniProtKB:O88382PMID:12589829UniProt 
Magi2Ratprotein binding enablesIPIUniProtKB:Q63226PMID:12589829UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Grid2  (glutamate ionotropic receptor delta type subunit 2)
Magi2  (membrane associated guanylate kinase, WW and PDZ domain containing 2)

Objects referenced in this article
Gene Grid1 glutamate ionotropic receptor delta type subunit 1 Rattus norvegicus

Additional Information