RGD Reference Report - Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus. - Rat Genome Database

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Chronic nicotine and smoking exposure decreases GABA(B1) receptor expression in the rat hippocampus.

Authors: Li, SP  Park, MS  Bahk, JY  Kim, MO 
Citation: Li SP, etal., Neurosci Lett 2002 Dec 13;334(2):135-9.
RGD ID: 632820
Pubmed: PMID:12435490   (View Abstract at PubMed)

Nicotine and smoking have long been proved to play an important role in cognition and memory in the hippocampus. This effect is closely related to the gamma-aminobutyric acid (GABA)ergic system. Previous research has focused on functional and pharmacological aspects of nicotine's modulation activity. In this study, the effects of nicotine and different doses of smoking on GABA(B1) expression in the rat hippocampus have been examined using in situ hybridization and RNase protection assay. GABA(B1) receptor mRNAs were intensely expressed in the CA1, CA2, CA3, and dentate gyrus areas of the hippocampus. Nicotine and smoking doses dependently decreased GABA(B1) receptor expression in the hippocampus. These results revealed new aspects of nicotine's modulation on GABA(B) receptor, and on learning and memory.




Biological Process

  
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Original Reference(s)
Gabbr1Ratresponse to nicotine  IEP  RGD 


Genes (Rattus norvegicus)
Gabbr1  (gamma-aminobutyric acid type B receptor subunit 1)