RGD Reference Report - Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony. - Rat Genome Database

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Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony.

Authors: Kato, N  Mashimo, T  Nabika, T  Cui, ZH  Ikeda, K  Yamori, Y 
Citation: Kato N, etal., J Hypertens 2003 Feb;21(2):295-303.
RGD ID: 629623
Pubmed: PMID:12569259   (View Abstract at PubMed)
DOI: DOI:10.1097/01.hjh.0000052428.12292.3e   (Journal Full-text)

OBJECTIVES Although several quantitative trait loci for blood pressure have been reported in stroke-prone spontaneously hypertensive rats (SHRSP), the results are not always concordant among different crosses. To evaluate potential confounding factors in linkage analysis, we performed genome-wide screens in F populations derived from SHRSP and Wistar-Kyoto rats of a Japanese colony.(2)METHODS Two F cohorts were independently produced: F -1 (110 male and 110 female rats), and F -2 (174 male and 184 female rats). Blood pressure was measured longitudinally (from 2 to 5 months of age and 1 month after salt-loading) in F -1, while it was measured at 13 weeks of age in F -2. Subsequent to an initial screen with 251 markers in F -1 male progeny, 170 markers were selected and characterized in the remaining populations.(2) (2) (2) (2) (2) (2)RESULTS When 578 rats were analyzed together, markers from five chromosomal regions showed significant linkage to blood pressure at 13 weeks of age. The strongest and the most consistent linkage was found on rat chromosome 1 (a maximal log of the odds score reached 8.3). In the other regions, the degree of linkage was more prominent in either of sexes. Some evidence of age-specific and sex-specific linkage was detected in five additional regions in the F -1 cohort. In the Japanese colony, however, there was no significant linkage to several chromosomal regions previously reported in other SHRSP colonies. (2)CONCLUSIONS Our data provide solid evidence of a chromosome-1 linkage and demonstrate the importance of aging, sex, and dietary manipulation in linkage analysis. Also, the combination of parental rat strains seems to be critical when searching for blood pressure quantitative trait loci.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bp117Rathypertension  IDA  RGD 
Bp118Rathypertension  IDA  RGD 
Bp119Rathypertension  IDA  RGD 
Bp120Rathypertension  IDA  RGD 
Bp121Rathypertension  IDA  RGD 
Bp122Rathypertension  IDA  RGD 
Bp123Rathypertension  IDA  RGD 
Bp124Rathypertension  IDA  RGD 
Bp125Rathypertension  IDA  RGD 
Bp126Rathypertension  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View
Objects Annotated

QTLs
Bp117  (Blood pressure QTL 117)
Bp118  (Blood pressure QTL 118)
Bp119  (Blood pressure QTL 119)
Bp120  (Blood pressure QTL 120)
Bp121  (Blood pressure QTL 121)
Bp122  (Blood pressure QTL 122)
Bp123  (Blood pressure QTL 123)
Bp124  (Blood pressure QTL 124)
Bp125  (Blood pressure QTL 125)
Bp126  (Blood pressure QTL 126)

Strains
SHRSP/A3Izm  (NA)
WKY/Izm  (Wistar-Kyoto)

Objects referenced in this article
Marker D9Wox18 D9Wox18 Rattus norvegicus
Strain SHRSP Spontaneously Hypertensive Rat, Stroke Prone Rattus norvegicus
Strain SHRSP/Bbb null Rattus norvegicus
Strain WKY/Bbb null Rattus norvegicus

Additional Information