RGD Reference Report - A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet. - Rat Genome Database

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A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet.

Authors: Bottger, A  Lankhorst, E  Van Lith, HA  Van Zutphen, LF  Zidek, V  Musilova, A  Simakova, M  Poledne, R  Bila, V  Koen, V  Pravenec, M 
Citation: Bottger A, etal., Biochem Biophys Res Commun 1998 May 8;246(1):272-5.
RGD ID: 629576
Pubmed: PMID:9600105   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1998.8596   (Journal Full-text)

Liver cholesterol concentration in rats fed a high cholesterol diet, is under genetic control which is supported by significant differences observed among inbred strains. For instance, the Brown Norway (BN-Lx/Cub) rat developed a twofold higher liver cholesterol concentration than the spontaneously hypertensive rat (SHR/Ola). In the current study, we used 30 recombinant inbred (RI) strains, derived from BN-Lx and SHR progenitors, to locate quantitative trait loci (QTL) that are responsible for differences in liver cholesterol concentrations between the BN-Lx and SHR strains. The heritability of liver cholesterol was estimated to be 0.55 and a significant association was detected between concentration of liver cholesterol and the D10Cebrp1016s2 marker on chromosome 10 (lod score = 3.3); this putative QTL was responsible for nearly 64% of additive genetic variability and thus represents a major genetic determinant of liver cholesterol concentration. Liver cholesterol concentrations significantly correlated with intermediate density lipoprotein (IDL) cholesterol levels.



Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
Hpcl1Ratabnormal cellular cholesterol metabolism  IAGP  RGD 
Hpcl1Ratincreased cholesterol level  IAGP  RGD 

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QTLs
Hpcl1  (Hepatic cholesterol level QTL 1)

Strains
BXH/Ipcv  (NA) HXB-1-43/Ipcv  (NA)

Strain BN-Lx/Cub Brown Norway with polydactyly-luxate Rattus norvegicus