RGD Reference Report - A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet. - Rat Genome Database
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A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet.

Authors: Bottger, A  Lankhorst, E  Van Lith, HA  Van Zutphen, LF  Zidek, V  Musilova, A  Simakova, M  Poledne, R  Bila, V  Koen, V  Pravenec, M 
Citation: Bottger A, etal., Biochem Biophys Res Commun 1998 May 8;246(1):272-5.
RGD ID: 629576
Pubmed: (View Article at PubMed) PMID:9600105
DOI: Full-text: DOI:10.1006/bbrc.1998.8596

Liver cholesterol concentration in rats fed a high cholesterol diet, is under genetic control which is supported by significant differences observed among inbred strains. For instance, the Brown Norway (BN-Lx/Cub) rat developed a twofold higher liver cholesterol concentration than the spontaneously hypertensive rat (SHR/Ola). In the current study, we used 30 recombinant inbred (RI) strains, derived from BN-Lx and SHR progenitors, to locate quantitative trait loci (QTL) that are responsible for differences in liver cholesterol concentrations between the BN-Lx and SHR strains. The heritability of liver cholesterol was estimated to be 0.55 and a significant association was detected between concentration of liver cholesterol and the D10Cebrp1016s2 marker on chromosome 10 (lod score = 3.3); this putative QTL was responsible for nearly 64% of additive genetic variability and thus represents a major genetic determinant of liver cholesterol concentration. Liver cholesterol concentrations significantly correlated with intermediate density lipoprotein (IDL) cholesterol levels.

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Objects Annotated

QTLs
Hpcl1  (Hepatic cholesterol level QTL 1)

Objects referenced in this article
0 BN-Lx/Cub Brown Norway with polydactyly-luxate All species
0 BXH/Ipcv null All species
0 HXB-1-43/Ipcv null All species

Additional Information