RGD Reference Report - Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve. - Rat Genome Database

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Identification of genes that are downregulated in the absence of the POU domain transcription factor pou3f1 (Oct-6, Tst-1, SCIP) in sciatic nerve.

Authors: Bermingham JR, JR  Shumas, S  Whisenhunt, T  Sirkowski, EE  O'Connell, S  Scherer, SS  Rosenfeld, MG 
Citation: Bermingham JR Jr, etal., J Neurosci 2002 Dec 1;22(23):10217-31.
RGD ID: 628407
Pubmed: PMID:12451123   (View Abstract at PubMed)
PMCID: PMC6758772   (View Article at PubMed Central)

Despite the importance of myelinating Schwann cells in health and disease, little is known about the genetic mechanisms underlying their development. The POU domain transcription factor pou3f1 (Tst-1, SCIP, Oct-6) is required for the normal differentiation of myelinating Schwann cells, but its precise role requires identification of the genes that it regulates. Here we report the isolation of six genes whose expression is reduced in the absence of pou3f1. Only one of these genes, the fatty acid transport protein P2, was known previously to be expressed in Schwann cells. The LIM domain proteins cysteine-rich protein-1 (CRP1) and CRP2 are expressed in sciatic nerve and induced by forskolin in cultured Schwann cells, but only CRP2 requires pou3f1 for normal expression. pou3f1 appears to require the claw paw gene product for activation of at least some of its downstream effector genes. Expression of the novel Schwann cell genes after nerve injury suggests that they are myelin related. One of the genes, tramdorin1, encodes a novel amino acid transport protein that is localized to paranodes and incisures. Our results suggest that pou3f1 functions to activate gene expression in the differentiation of myelinating Schwann cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pou3f1Ratregulation of DNA-templated transcription  TAS  RGD 

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pou3f1RatDNA-binding transcription factor activity  TAS  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pou3f1  (POU class 3 homeobox 1)

Objects referenced in this article
Gene Slc36a2 solute carrier family 36 (proton/amino acid symporter), member 2 Mus musculus
Gene Slc36a2 solute carrier family 36 member 2 Rattus norvegicus

Additional Information