RGD Reference Report - Detection of a quantitative trait locus for intramuscular fat accumulation using the OLETF rat. - Rat Genome Database

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Detection of a quantitative trait locus for intramuscular fat accumulation using the OLETF rat.

Authors: Tanomura, H  Miyake, T  Taniguchi, Y  Manabe, N  Kose, H  Matsumoto, K  Yamada, T  Sasaki, Y 
Citation: Tanomura H, etal., J Vet Med Sci 2002 Jan;64(1):45-50.
RGD ID: 619672
Pubmed: PMID:11853145   (View Abstract at PubMed)

The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese type 2 diabetes. We showed that the OLETF rat exhibits higher levels of intramuscular fat content in Musculus longissimus as compared to the Fischer-344 (F344) rat. Our investigation was designed to identify quantitative trait loci (QTLs) contributing to the increased levels of intramuscular fat content by performing a whole-genome search using 108 F2 intercross obtained by mating the OLETF and the F344 rats. We identified one QTL responsible for intramuscular fat accumulation on rat chromosome 1 with a maximum lod score of 3.4, which accounts for 5% of the total variance. As expected, the OLETF allele corresponds to the increased levels of intramuscular fat content.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Bw61Ratobesity  IDA  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
OLETFRatabnormal adipose tissue amount  IAGP  RGD 
Bw61Ratabnormal adipose tissue distribution  QTM  RGD 

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Objects Annotated

QTLs
Bw61  (Body weight QTL61)

Strains
F344/NRrrc  (NA)
OLETF  (Otsuka Long-Evans Tokushima fatty)


Additional Information