RGD Reference Report - Genetic analysis of metabolic defects in the spontaneously hypertensive rat. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Genetic analysis of metabolic defects in the spontaneously hypertensive rat.

Authors: Pravenec, M  Zidek, V  Musilova, A  Simakova, M  Kostka, V  Mlejnek, P  Kren, V  Krenova, D  Bila, V  Mikova, B  Jachymova, M  Horky, K  Kazdova, L  St Lezin, E  Kurtz, TW 
Citation: Pravenec M, etal., Mamm Genome 2002 May;13(5):253-8.
RGD ID: 619533
Pubmed: PMID:12016513   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-001-2078-Y   (Journal Full-text)

Abnormalities in carbohydrate and lipid metabolism are common in patients with essential hypertension and in the spontaneously hypertensive rat (SHR). To identify chromosome regions contributing to this clustering of cardiovascular risk factors in the SHR, we searched for quantitative trait loci (QTL) associated with insulin resistance, glucose intolerance, and dyslipidemia by using the HXB/BXH recombinant inbred (RI) strains. Analysis of variance in RI strains suggested significant effects of genetic factors. A genome screening of the RI strains with more than 700 markers revealed QTL significantly associated with insulin resistance on Chromosomes (Chrs) 3 and 19. The Chr 19 QTL was confirmed by testing a previously derived SHR-19 congenic strain: transfer of a Chr 19 segment delineated by markers D19Rat57 and D19Mit7 from the Brown Norway (BN/Cr) strain onto the genetic background of the SHR/Ola was associated with decreased insulin and glucose concentrations and ameliorated insulin resistance at the tissue level. These findings suggest that closely linked genes on Chr 19, or perhaps even a single gene with pleiotropic effects, influence the clustering of metabolic disturbances in the SHR-BN model.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gluco6Ratglucose intolerance  IAGP  RGD 
Gluco6RatInsulin Resistance  IAGP  RGD 
Insglur1RatInsulin Resistance  IAGP  RGD 
Insglur2RatInsulin Resistance  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gluco6Ratabnormal glucose tolerance  IAGP  RGD 
Gluco6Ratimpaired glucose tolerance  IAGP  RGD 
Insglur1Ratinsulin resistance  IAGP  RGD 
Insglur2Ratinsulin resistance  IAGP  RGD 
Objects Annotated

QTLs
Gluco6  (Glucose level QTL 6)
Insglur1  (Insulin/glucose ratio QTL 1)
Insglur2  (Insulin/glucose ratio QTL 2)

Strains
BXS/Ipcv  (NA)

Objects referenced in this article
Strain SHR.BN-(D19Rat57-D19Mit7)/Ipcv null Rattus norvegicus

Additional Information