RGD Reference Report - Genetic analysis of metabolic defects in the spontaneously hypertensive rat. - Rat Genome Database

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Genetic analysis of metabolic defects in the spontaneously hypertensive rat.

Authors: Pravenec, M  Zidek, V  Musilova, A  Simakova, M  Kostka, V  Mlejnek, P  Kren, V  Krenova, D  Bila, V  Mikova, B  Jachymova, M  Horky, K  Kazdova, L  St Lezin, E  Kurtz, TW 
Citation: Pravenec M, etal., Mamm Genome 2002 May;13(5):253-8.
RGD ID: 619533
Pubmed: PMID:12016513   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-001-2078-Y   (Journal Full-text)

Abnormalities in carbohydrate and lipid metabolism are common in patients with essential hypertension and in the spontaneously hypertensive rat (SHR). To identify chromosome regions contributing to this clustering of cardiovascular risk factors in the SHR, we searched for quantitative trait loci (QTL) associated with insulin resistance, glucose intolerance, and dyslipidemia by using the HXB/BXH recombinant inbred (RI) strains. Analysis of variance in RI strains suggested significant effects of genetic factors. A genome screening of the RI strains with more than 700 markers revealed QTL significantly associated with insulin resistance on Chromosomes (Chrs) 3 and 19. The Chr 19 QTL was confirmed by testing a previously derived SHR-19 congenic strain: transfer of a Chr 19 segment delineated by markers D19Rat57 and D19Mit7 from the Brown Norway (BN/Cr) strain onto the genetic background of the SHR/Ola was associated with decreased insulin and glucose concentrations and ameliorated insulin resistance at the tissue level. These findings suggest that closely linked genes on Chr 19, or perhaps even a single gene with pleiotropic effects, influence the clustering of metabolic disturbances in the SHR-BN model.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gluco6Ratglucose intolerance  IAGP  RGD 
Gluco6RatInsulin Resistance  IAGP  RGD 
Insglur1RatInsulin Resistance  IAGP  RGD 
Insglur2RatInsulin Resistance  IAGP  RGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Gluco6Ratabnormal glucose tolerance  IAGP  RGD 
Gluco6Ratimpaired glucose tolerance  IAGP  RGD 
Insglur1Ratinsulin resistance  IAGP  RGD 
Insglur2Ratinsulin resistance  IAGP  RGD 
Objects Annotated

Gluco6  (Glucose level QTL 6)
Insglur1  (Insulin/glucose ratio QTL 1)
Insglur2  (Insulin/glucose ratio QTL 2)

BXS/Ipcv  (NA)

Objects referenced in this article
Strain SHR.BN-(D19Rat57-D19Mit7)/Ipcv null Rattus norvegicus

Additional Information