RGD Reference Report - Differential splicing creates a diversity of transcripts from a neurospecific developmentally regulated gene encoding a protein with new zinc-finger motifs. - Rat Genome Database

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Differential splicing creates a diversity of transcripts from a neurospecific developmentally regulated gene encoding a protein with new zinc-finger motifs.

Authors: Buchman, VL  Ninkina, NN  Bogdanov, YD  Bortvin, AL  Akopian, HN  Kiselev, SL  Krylova, OYU  Anokhin, KV  Georgiev, GP 
Citation: Buchman VL, etal., Nucleic Acids Res 1992 Nov 11;20(21):5579-85.
RGD ID: 61670
Pubmed: PMID:1454523   (View Abstract at PubMed)
PMCID: PMC334389   (View Article at PubMed Central)

We have cloned a novel neurospecific gene, named neuro-d4, by differential screening a rat cerebral cortex cDNA library. Northern blot hybridization showed that neuro-d4 expression is restricted to neuronal tissues both in newborn and adult animals. The level of neuro-d4 mRNA in the rat central nervous system is high during the later stages of embryonic development and gradually decreases during the postnatal period. In situ hybridization suggests that the gene transcripts are localized in neuronal cell bodies. Nucleotide sequences of overlapped cDNA clones and all 12 exons in genomic clone were determined. The deduced protein has consensus sequences for a nuclear localization signal, a Kruppel-type zinc-finger and a new type of cysteine/histidine-rich motif resembling zinc-fingers. Several differential splicing variants were found, each of which influences the structure of the encoded protein.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Dpf1Ratnervous system development  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Dpf1  (double PHD fingers 1)


Additional Information