RGD Reference Report - Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior. - Rat Genome Database

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Steroid receptor coactivator-1 (SRC-1) mediates the development of sex-specific brain morphology and behavior.

Authors: Auger, AP  Tetel, MJ  McCarthy, MM 
Citation: Auger AP, etal., Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7551-5.
RGD ID: 5688261
Pubmed: (View Article at PubMed) PMID:10861018

Steroid hormone action during brain development exerts profound effects on reproductive physiology and behavior that last into adulthood. A variety of in vitro studies indicate that steroid receptors require nuclear receptor coactivators for efficient transcriptional activity. To determine the functional significance of the nuclear receptor coactivator SRC-1 in developing brain, we investigated the consequence of reducing SRC-1 protein during sexual differentiation of the brain. We report that reducing SRC-1 protein interferes with the defeminizing actions of estrogen in neonatal rat brain. Our data indicate that SRC-1 protein expression is critically involved in the hormone-dependent development of normal male reproductive behavior and brain morphology.

Annotation

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Ncoa1  (nuclear receptor coactivator 1)


Additional Information