RGD Reference Report - Autoantibodies recognizing the 27 carboxy-terminal amino acids of calpastatin are associated with secondary Sjogren syndrome in systemic lupus erythematosus.

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Autoantibodies recognizing the 27 carboxy-terminal amino acids of calpastatin are associated with secondary Sjogren syndrome in systemic lupus erythematosus.
Authors:	Salle, V Vittecoq, O Jouen-Beades, F Menard, JF Ducroix, JP Godin, M Le Loet, X Tron, F
Citation:	Salle V, etal., Lupus. 2004;13(10):800-4.
RGD ID:	5683622
Pubmed:	PMID:15540513 (View Abstract at PubMed)
The objective of this study was to determine in systemic lupus erythematosus (SLE) the prevalence and clinical significance of anticalpastatin antibodies (ACAST), an autoantibody population previously detected in sera from patients with various connective tissue diseases. Eighty-four patients with SLE (mean age: 30 years at diagnosis, females 77) that fulfilled ACR criteria were included in the study retrospectively. Several clinical and biological data were collected. ACAST were detected by a solid-phase enzyme linked immunosorbent assay (ELISA) using as antigen a synthetic peptide corresponding to the 27 C-terminal amino acids of calpastatin (CAST-C27). The prevalence of ACAST-C27 was 13% (11/84) in SLE patients. No correlation was found between the presence of ACAST-C27 and clinical manifestations such as thrombosis and vasculitis. Furthermore, no correlation was observed with the presence ofantiphospholipid antibodies (APL). However, we found a statistically significant association between the presence of ACAST-C27 and that of secondary Sjogren syndrome (P = 0.01). The conclusion is ACAST-C27 are not associated with thrombosis in SLE patients. The association observed between ACAST-C27 and secondary Sjogren syndrome suggests that ACAST-C27 might be useful in discriminating a clinical subgroup of SLE patients.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
CAST	Human	Sjogren's syndrome		IDA		associated with Lupus Erythematosus and Systemic	RGD
Cast	Rat	Sjogren's syndrome		ISO	CAST (Homo sapiens)	associated with Lupus Erythematosus and Systemic	RGD
Cast	Mouse	Sjogren's syndrome		ISO	CAST (Homo sapiens)	associated with Lupus Erythematosus and Systemic	RGD

Objects Annotated

Genes (Rattus norvegicus)

Cast (calpastatin)

Genes (Mus musculus)

Cast (calpastatin)

Genes (Homo sapiens)

CAST (calpastatin)

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Autoantibodies recognizing the 27 carboxy-terminal amino acids of calpastatin are associated with secondary Sjogren syndrome in systemic lupus erythematosus.