RGD Reference Report - Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation. - Rat Genome Database

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Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation.

Authors: John, AE  Thomas, MS  Berlin, AA  Lukacs, NW 
Citation: John AE, etal., Am J Pathol. 2005 Feb;166(2):345-53.
RGD ID: 4892197
Pubmed: PMID:15681819   (View Abstract at PubMed)
PMCID: PMC1602329   (View Article at PubMed Central)
DOI: DOI:10.1016/S0002-9440(10)62258-4   (Journal Full-text)

CCL28 is a recently identified chemokine ligand for CCR10 and CCR3 that has been identified in mucosal epithelial surfaces in diverse tissues. CCL28-mediated eosinophil chemotaxis and peroxidase release were inhibited by preincubation of cells with anti-CCR3. CCL28 was constitutively expressed in lung tissue collected from nonsensitized control mice but increased levels were found in mice sensitized and rechallenged with cockroach antigen (CRA). CCL28 levels peaked in the lungs 24 hours after intratracheal challenge with CRA, whereas eotaxin expression peaked at 8 hours. Increased expression of CCR3 but not CCR10 could be detected during the induction of the CRA-induced pulmonary inflammation. To investigate the role of CCL28 in allergic airway responses, mice were treated with CCL28 antiserum 1 hour before receiving the final CRA challenge. The level of airway hyperresponsiveness in mice treated with anti-CCL28 was significantly reduced at 24 hours, but not 8 hours, compared to mice receiving control serum. This reduction was not related to decreased Th2 cytokine, chemokine, or leukotriene levels at 24 hours although peribronchial eosinophilia was significantly reduced. Thus, CCL28 appears to play a role in regulating eosinophil recruitment to peribronchial regions of the lung possibly by coordinated temporal production with eotaxin.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CCL28Humanbronchial disease  ISOCcl28 (Mus musculus)Allergic Airway DiseaseRGD 
Ccl28Ratbronchial disease  ISOCcl28 (Mus musculus)Allergic Airway DiseaseRGD 
Ccl28Mousebronchial disease  IMP Allergic Airway DiseaseRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccl28  (C-C motif chemokine ligand 28)

Genes (Mus musculus)
Ccl28  (C-C motif chemokine ligand 28)

Genes (Homo sapiens)
CCL28  (C-C motif chemokine ligand 28)


Additional Information