RGD Reference Report - Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction. - Rat Genome Database

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Iron deficiency in the rat. Physiological and biochemical studies of muscle dysfunction.

Authors: Finch, C A  Miller, L R  Inamdar, A R  Person, R  Seiler, K  Mackler, B 
Citation: Finch CA, etal., J Clin Invest. 1976 Aug;58(2):447-53. doi: 10.1172/JCI108489.
RGD ID: 488078620
Pubmed: PMID:956378   (View Abstract at PubMed)
PMCID: PMC333200   (View Article at PubMed Central)
DOI: DOI:10.1172/JCI108489   (Journal Full-text)

Work performance on a treadmill has been evaluated in normal and iron-deficient rats. Anemia was removed as a variable by adjusting the hemoglobin of all animals to the same concentration. At a hemoglobin compatible with normal work performance, iron-deficient animals showed a marked impairment of running ability as compared to control animals. Iron therapy corrected the disability within 4 days. Concentrations of the cytochrome pigments and myoglobin, and rates of oxidative phosphorylation with pyruvate-malate, succinate, and alpha-glycerophosphate as substrates were all reduced in mitochondrial preparations from skeletal muscle of iron-deficient rats, but only the rate of phosphorylation with alpha-glycerophosphate as substrate increased significantly and in parallel with the recovery in work performance of the iron-deficient rats treated with iron dextran.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MBHumaniron deficiency anemia  ISOMb (Rattus norvegicus)protein:decreased expression:skeletal muscleRGD 
MbRatiron deficiency anemia  IEP protein:decreased expression:skeletal muscleRGD 
MbMouseiron deficiency anemia  ISOMb (Rattus norvegicus)protein:decreased expression:skeletal muscleRGD 


Genes (Rattus norvegicus)
Mb  (myoglobin)

Genes (Mus musculus)
Mb  (myoglobin)

Genes (Homo sapiens)
MB  (myoglobin)