RGD Reference Report - Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. - Rat Genome Database

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Surfactant protein C: hormonal control of SP-C mRNA levels in vitro.

Authors: Veletza, SV  Nichols, KV  Gross, I  Lu, H  Dynia, DW  Floros, J 
Citation: Veletza SV, etal., Am J Physiol. 1992 Jun;262(6 Pt 1):L684-7.
RGD ID: 4143483
Pubmed: PMID:1319687   (View Abstract at PubMed)

We have studied hormonal regulation of the surfactant protein C (SP-C) in fetal 18-dah rat lung explants. SP-C mRNA was detected in Northern blots with a specific rat SP-C cDNA probe and quantified by densitometry. Treatment of the explants with dexamethasone resulted in a dose-dependent increase of the SP-C mRNA level. Transcriptional assays have shown that the regulation of SP-C mRNA by dexamethasone involves a transcriptional step. Administration of the cAMP analogues, 8-bromoadenosine 3',5'-cyclic monophosphate (8-BrcAMP) or dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP), produced a dose-dependent increase of SP-C mRNA levels, with maximum stimulation observed at 200 microM. The thyroid hormone T3 had no effect on SP-C mRNA levels, whether administered alone or in combination with dexamethasone. Variation in the effects of the above hormones on three surfactant protein mRNAs, SP-A, SP-B and SP-C, indicates that the hormonal regulation of the surfactant proteins is a complex process and that each gene is, in part, differentially regulated.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
SftpcRatresponse to cAMP  IEP  RGD 
SftpcRatresponse to glucocorticoid  IEP  RGD 


Genes (Rattus norvegicus)
Sftpc  (surfactant protein C)