RGD Reference Report - Surfactant protein C: hormonal control of SP-C mRNA levels in vitro. - Rat Genome Database

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Surfactant protein C: hormonal control of SP-C mRNA levels in vitro.

Authors: Veletza, SV  Nichols, KV  Gross, I  Lu, H  Dynia, DW  Floros, J 
Citation: Veletza SV, etal., Am J Physiol. 1992 Jun;262(6 Pt 1):L684-7.
RGD ID: 4143483
Pubmed: PMID:1319687   (View Abstract at PubMed)

We have studied hormonal regulation of the surfactant protein C (SP-C) in fetal 18-dah rat lung explants. SP-C mRNA was detected in Northern blots with a specific rat SP-C cDNA probe and quantified by densitometry. Treatment of the explants with dexamethasone resulted in a dose-dependent increase of the SP-C mRNA level. Transcriptional assays have shown that the regulation of SP-C mRNA by dexamethasone involves a transcriptional step. Administration of the cAMP analogues, 8-bromoadenosine 3',5'-cyclic monophosphate (8-BrcAMP) or dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP), produced a dose-dependent increase of SP-C mRNA levels, with maximum stimulation observed at 200 microM. The thyroid hormone T3 had no effect on SP-C mRNA levels, whether administered alone or in combination with dexamethasone. Variation in the effects of the above hormones on three surfactant protein mRNAs, SP-A, SP-B and SP-C, indicates that the hormonal regulation of the surfactant proteins is a complex process and that each gene is, in part, differentially regulated.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SftpcRatresponse to cAMP  IEP  RGD 
SftpcRatresponse to glucocorticoid  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sftpc  (surfactant protein C)


Additional Information