RGD Reference Report - Expression of cdc25A and cdc25B phosphatase in breast carcinoma. - Rat Genome Database

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Expression of cdc25A and cdc25B phosphatase in breast carcinoma.

Authors: Ito, Y  Yoshida, H  Uruno, T  Takamura, Y  Miya, A  Kuma, K  Miyauchi, A 
Citation: Ito Y, etal., Breast Cancer. 2004;11(3):295-300.
RGD ID: 4105449
Pubmed: PMID:15550849   (View Abstract at PubMed)

BACKGROUND: Previous studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells. In this study, we investigated the expression of these phosphatases in breast carcinoma to elucidate their significance. METHODS: We immunohistochemically examined cdc25B and cdc25A expression in 46 cases of breast carcinoma. RESULTS: Cdc25B and cdc25A were negative or only equivocally expressed in glandular epithelial cells. In breast carcinoma, 56.5% of cases had high levels of cdc25B expression. Interestingly, the expression of cdc25B was significantly lower in cases with biologically aggressive phenotypes. The cdc25A level was high in 69.6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters. CONCLUSION: These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CDC25BHumanbreast carcinoma disease_progressionIEP  RGD 
Cdc25bRatbreast carcinoma disease_progressionISOCDC25B (Homo sapiens) RGD 
Cdc25bMousebreast carcinoma disease_progressionISOCDC25B (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdc25b  (cell division cycle 25B)

Genes (Mus musculus)
Cdc25b  (cell division cycle 25B)

Genes (Homo sapiens)
CDC25B  (cell division cycle 25B)


Additional Information